RTECS:CP8000000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

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Barbituric acid

RTECS #: CP8000000

CAS #: 67-52-7

UPDATE: May 2008 MW: 128.10 MF: C₄H₄N₂O₃

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

2,4,6 (1H,3H,5H) - Pyrimidinetrione

2,4,6 - Pyrimidinetriol

2,4,6 - Pyrimidinetrione

2,4,6 - Trihydroxypyrimidine

2,4,6 - Trioxohexahydropyrimidine

6 - Hydroxyuracil

Hydrouracil, 6 - hydroxy -

Malonylurea

Pyrimidinetriol

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 535 mg/m³/4 hour Behavioral: Somnolence (general depressed activity)

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Renal function tests depressed TOVEFN (1),47,2003
inhalation
rat lowest published toxic concentration: 535 mg/m³/4 hour Kidney, Ureter, and Bladder: Other changes in urine composition TOVEFN (1),47,2003
intraperitoneal
mouse lethal dose (50 percent kill): 505 mg/kg N/R TOVEFN (1),47,2003
oral
mouse lethal dose (50 percent kill): >7,500 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Behavioral: Ataxia TOVEFN (1),47,2003
oral
rat lethal dose (50 percent kill): >5 gm/kg N/R TXAPA9 18,185,1971
oral
rat lethal dose (50 percent kill): 13,400 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Behavioral: Ataxia TOVEFN (1),47,2003

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 100 mg/m³/30 day- intermittent Behavioral: Somnolence (general depressed activity)

Liver: Liver function tests impaired TOVEFN (1),47,2003

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TOPADD 33,63,2005

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m³, JUN2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81718;
Number of Industries 1;
Total Number of Facilities 28;
Number of Occupations 2;
Total Number of Employees Exposed 700
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81718;
Number of Industries 4;
Total Number of Facilities 79;
Number of Occupations 5;
Total Number of Employees Exposed 3,529;
Total Number of Female Employees Exposed 1,481

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

REFERENCES:
CODEN
REFERENCE

TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
Drug

ALT CAS #: 32267-40-6
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