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Arginine, monohydrochloride, L -

RTECS #: CF1995500

CAS #: 1119-34-2

UPDATE: March 2000 MW: 210.70 MF: C6H14N4O2•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Argamine
  2. Arginine, hydrochloride, L -
  3. Arginine monohydrochloride
  4. Arginine hydrochloride
  5. Argivene
  6. Detoxargin
  1. L - Arginine hydrochloride
  2. L - Arginine, monohydrochloride
  3. Levargin
  4. Minophagen A
  5. R - Gene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 90 mg/kg (1-6 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system AJEBAK 51,553,1973


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 3,793 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease 		ABBIA4 58,253,1955
intravenous
child 		lowest published lethal dose: 3,900 mg/kg/30 minute- continuous Brain and Coverings: Other degenerative changes

Cardiac: Other changes

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis 		JTCTDW 35,621,1997
oral
rat 		lethal dose (50 percent kill): 12 gm/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		JPMSAE 62,49,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81859;
Number of Industries 2;
Total Number of Facilities 86;
Number of Occupations 3;
Total Number of Employees Exposed 857
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81859;
Number of Industries 3;
Total Number of Facilities 585;
Number of Occupations 13;
Total Number of Employees Exposed 5,477;
Total Number of Female Employees Exposed 2,954


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951-
AJEBAK Australian Journal of Experimental Biology and Medical Science. (Adelaide, S.A., Australia) V.1-64, 1924-86.
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-

Used as an AMMONIA detoxicant for hepatic failure and diagnostic aid for pituitary function

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data

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