RTECS:CE8863000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

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Arbutin

RTECS #: CE8863000

CAS #: 497-76-7

UPDATE: November 2007 MW: 272.28 MF: C₁₂H₁₆O₇

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

4 - Hydroxyphenyl - beta - D - glucopyranoside

Hydroquinone - beta - D - glucopyranoside

Ursin

Uvasol

beta - Arbutin

beta - D - Glucopyranoside, 4 - hydroxyphenyl - (9CI)

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
specific locus test hamster lung 0.3 mmol/L/3 day (+enzymatic activation step) FCTOD7 44,1940,2006

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 13,600 mg/kg (14 day prior to copulation/20 day pregnant) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) IYKEDH 19,282,1988

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
mouse lowest published toxic dose: 0.25 gm/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation

Lung, Thorax, or Respiration: Other changes BPBLEO 28,1106,2005

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1290;
Number of Industries 1;
Total Number of Facilities 68;
Number of Occupations 3;
Total Number of Employees Exposed 995;
Total Number of Female Employees Exposed 745

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Natural Product

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