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Anisole, p - methyl -

RTECS #: BZ8780000

CAS #: 104-93-8

UPDATE: February 2006 MW: 122.18 MF: C8H10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1 - Methoxy - 4 - methylbenzene
  2. 4 - Methoxytoluene
  3. 4 - Methyl - 1 - methoxybenzene
  4. 4 - Methylphenol methyl ether
  5. Benzene, 1 - methoxy - 4 - methyl - (9CI)
  6. Methyl p - tolyl ether
  1. p - Cresol methyl ether
  2. p - Cresyl methyl ether
  3. p - Methoxytoluene
  4. p - Methylanisole
  5. p - Tolyl methyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour moderate FCTXAV 12,393,1974


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose : >500 mg/kg N/R CBCCT* 6,214,1954
oral
rat 		lethal dose (50 percent kill): 1,920 mg/kg N/R FCTXAV 12,393,1974
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 12,393,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 3,360 mg/kg/4 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Other changes 		FCTXAV 12,393,1974


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83207;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 2;
Total Number of Employees Exposed 207
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83207;
Number of Industries 8;
Total Number of Facilities 1,443;
Number of Occupations 10;
Total Number of Employees Exposed 13,288;
Total Number of Female Employees Exposed 9,258


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.

Used as intermediate for aldehydes in flavors and fragrances and in ZINC plating

RTECS Compound Description:
   Natural Product
   Primary Irritant

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