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Anisole, 6 - t - butyl - 3 - methyl - 2,4 - dinitro -

RTECS #: BZ8575000

CAS #: 83-66-9

UPDATE: September 1999 MW: 268.30 MF: C12H16N2O5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - (1,1 - Dimethylethyl) - 2 - methoxy - 4 - methyl - 3,5 - dinitrobenzene
  2. 2,6 - Dinitro - 3 - methoxy - 4 - tert - butyltoluene
  3. 4 - tert - Butyl - 3 - methoxy - 2,6 - dinitrotoluene
  4. 6 - tert - Butyl - 3 - methyl - 2,4 - dinitroanisole
  5. Amber must
  1. Ambrette musk
  2. Artificial musk ambrette
  3. Benzene, 1 - (1,1 - dimethylethyl) - 2 - methoxy - 4 - methyl - 3,5 - dinitro - (9CI)
  4. Musk ambrette (artificial)
  5. Synthetic musk ambrette


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour moderate FCTXAV 13,875,1975


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 2 µmol/plate (+enzymatic activation step) FCTOD7 21,707,1983
mutation in microorganisms Salmonella typhimurium 100 µg/plate (-enzymatic activation step) FCTOD7 24,27,1986
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		10 mmol/L FCTOD7 21,707,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): 339 mg/kg Lung, Thorax, or Respiration: Respiratory stimulation

Skin and Appendages: Other: Hair 		FCTXAV 2,327,1964
skin
rabbit 		lethal dose (50 percent kill): >2 gm/kg N/R FCTXAV 13,875,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 10,500 mg/kg/20 week- intermittent Behavioral: Muscle weakness

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 10,405,1967
oral
rat 		lowest published toxic dose: 6,300 mg/kg/12 week- continuous Brain and Coverings: Demyelination

Spinal Cord: Demyelination

Peripheral Nerve and Sensation: Structural change in nerve or sheath 		TXAPA9 75,571,1984
skin
rat 		lowest published toxic dose: 6,750 mg/kg/90 day- intermittent Spinal Cord: Demyelination

Peripheral Nerve and Sensation: Structural change in nerve or sheath

Related to Chronic Data: Changes in testicular weight 		FCTOD7 28,55,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 65,477,1996
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 65,477,1996
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 65,477,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83003;
Number of Industries 4;
Total Number of Facilities 260;
Number of Occupations 20;
Total Number of Employees Exposed 23,082
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83003;
Number of Industries 11;
Total Number of Facilities 1,567;
Number of Occupations 16;
Total Number of Employees Exposed 22,736;
Total Number of Female Employees Exposed 16,492


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

Click Here for Additional Information about RTECS

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