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Anisole, p - allyl -

RTECS #: BZ8225000

CAS #: 140-67-0

UPDATE: May 2008 MW: 148.22 MF: C10H12O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - Methoxy - 4 - (2 - propenyl) benzene
  2. 4 - Allyl - 1 - methoxybenzene
  3. Chavicol methyl ether
  4. Esdragol
  5. Esdragon
  6. Estragole
  7. Isoanethole
  1. Methyl chavicol
  2. NCI - C60946
  3. Tarragon
  4. p - Allylanisole
  5. p - Allylmethoxybenzene
  6. p - Methoxyallylbenzene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour moderate FCTXAV 14,603,1976


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
body fluid assay rat
Salmonella typhimurium 		2,500 mg/kg NUCADQ 1,10,1979
DNA adduct intraperitoneal
mouse 		80 mg/kg CRNGDP 5,1613,1984
unscheduled DNA synthesis rat liver 1 mmol/L FCTOD7 28,537,1990
unscheduled DNA synthesis oral
rat 		2 gm/kg MUREAV 325,129,1994
mutation in microorganisms Salmonella typhimurium 20 µmol/plate (-enzymatic activation step) MUREAV 60,143,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 111 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		CNREA8 47,2275,1987
oral
mouse 		lowest published toxic dose: 97 gm/kg/1 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		CNREA8 43,1124,1983
oral
mouse 		toxic dose : 195 gm/kg/1 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Liver: Angiosarcoma 		CNREA8 43,1124,1983
subcutaneous
mouse 		lowest published toxic dose: 140 mg/kg/22 day- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		JNCIAM 57,1323,1976


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,260 mg/kg Behavioral: Antipsychotic COREAF 246,1465,1958
intraperitoneal
rat 		lethal dose (50 percent kill): 1,030 mg/kg Behavioral: Antipsychotic COREAF 246,1465,1958
intravenous
rat 		lowest published toxic dose: 10 mg/kg Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section 		CEXPB9 33,238,2006
oral
mouse 		lethal dose (50 percent kill): 1,250 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma 		FCTXAV 2,327,1964
oral
rat 		lethal dose (50 percent kill): 1,230 mg/kg N/R FCTXAV 14,603,1976
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 14,603,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
FCTOD7 40,851,2002
TOXICOLOGY REVIEW
MUREAV 574,124,2005
TOXICOLOGY REVIEW
MUREAV 574,124,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5058;
Number of Industries 2;
Total Number of Facilities 668;
Number of Occupations 6;
Total Number of Employees Exposed 9,128;
Total Number of Female Employees Exposed 6,777


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in perfumes and as a flavor in foods and liqueurs
NTP Carcinogenesis studies; selected, October 2000


REFERENCES:

CODEN
REFERENCE
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NUCADQ Nutrition and Cancer. (Franklin Institute Press, POB 2266, Phildelphia, PA 19103) V.1- 1978-

Used in perfumes and as a flavor in foods and liqueurs

RTECS Compound Description:
   Tumorigen
   Mutagen
   Natural Product
   Primary Irritant

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