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o - Anisidine, hydrochloride

RTECS #: BZ6500000

CAS #: 134-29-2

UPDATE: February 2009 MW: 159.63 MF: C7H9NO•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - Aminoanisole hydrochloride
  2. 2 - Anisidine hydrochloride
  3. 2 - Methoxy - 1 - aminobenzene hydrochloride
  4. 2 - Methoxyaniline hydrochloride
  5. 2 - Methoxybenzenamine hydrochloride
  6. 2 - Methoxybenzeneamine hydrochloride
  7. Benzenamine, 2 - methoxy - , hydrochloride (9CI)
  1. C.I. 37115
  2. Fast Red BB Base
  3. NCI - C03747
  4. o - Aminoanisole hydrochloride
  5. o - Anisylamine hydrochloride
  6. o - Methoxyaniline hydrochloride
  7. o - Methoxyphenylamine hydrochloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Escherichia coli 1 mg/plate (+enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
mutation in microorganisms Salmonella typhimurium 10 µg/plate (-enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
mutation in mammalian somatic cells oral
mouse 		2,250 mg/kg/3 day- continuous CRNGDP 15,2291,1994
morphological transform rat embryo 195 µg/plate JJATDK 1,190,1981
specific locus test oral
Drosophila melanogaster 		500 µmol/L EMMUEG 24,75,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 721 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		NCITR* NCI-TR-89,1978
oral
mouse 		toxic dose : 216 gm/kg/78 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		NCITR* NCI-TR-89,1978
oral
mouse 		toxic dose : 1,803 gm/kg/1 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		IMEMDT 27,63,1982
oral
mouse 		toxic dose : 3,605 gm/kg/1 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		IMEMDT 27,63,1982
oral
rat 		lowest published toxic dose: 180 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Kidney, Ureter, and Bladder: Kidney tumors 		NCITR* NCI-TR-89,1978
oral
rat 		toxic dose : 360 gm/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Kidney, Ureter, and Bladder: Kidney tumors 		NCITR* NCI-TR-89,1978
oral
rat 		toxic dose : 2,905 gm/kg/83 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		IMEMDT 27,63,1982
oral
rat 		toxic dose : 5,810 gm/kg/83 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		IMEMDT 27,63,1982


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 58,800 mg/kg/7 week- continuous Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NCITR* NCI-TR-89,1978
oral
rat 		lowest published toxic dose: 73,500 mg/kg/7 week- continuous Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NCITR* NCI-TR-89,1978


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 27,63,1982
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 27,63,1982
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMSUDL 7,56,1987
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
BCLPT* 96,131,2005
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X8301;
Number of Industries 1;
Total Number of Facilities 50;
Number of Occupations 3;
Total Number of Employees Exposed 1,108


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,rat NCITR* NCI-TR-89,1978
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

RTECS Compound Description:
   Tumorigen
   Mutagen

Click Here for Additional Information about RTECS

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