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p - Anisaldehyde

RTECS #: BZ2625000

CAS #: 123-11-5

UPDATE: February 2006 MW: 136.16 MF: C8H8O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 4 - Methoxybenzaldehyde
  2. Anisic aldehyde
  3. Aubepine
  1. Crategine
  2. p - Methoxybenzaldehyde


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour moderate FCTXAV 12,823,1974


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage mouse lymphocyte 7,020 µmol/L MUREAV 203,155,1988
mutation in mammalian somatic cells mouse lymphocyte 3,560 µmol/L MUTAEX 3,193,1988
sister chromatid exchange human lymphocyte 1 mmol/L MUREAV 206,17,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
guinea pig 		lethal dose (50 percent kill): 1,260 mg/kg Behavioral: Somnolence (general depressed activity) FCTXAV 2,327,1964
oral
mouse 		lethal dose (50 percent kill): 1,859 mg/kg Gastrointestinal: Necrotic changes

Gastrointestinal: Other changes

Liver: Fatty liver degeneration 		GISAAA 58(8),20,1993
oral
mouse 		lethal dose (50 percent kill): 1,858.6 mg/kg N/R GISAAA -,20,1993
oral
mouse 		lowest published toxic dose: 1,850 mg/kg Gastrointestinal: Necrotic changes GISAAA -,20,1993
oral
rat 		lethal dose (50 percent kill): 1,510 mg/kg Behavioral: Somnolence (general depressed activity) FCTXAV 2,327,1964
oral
rat 		lethal dose (50 percent kill): 1,847.8 mg/kg N/R GISAAA -,20,1993
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 12,823,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 55,200 µg/kg/30 day- intermittent Cardiac: Changes in heart weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in other cell count (unspecified) 		GISAAA 58(8),20,1993
oral
rat 		lowest published toxic dose: 18.4 mg/kg/10 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Blood: Luekopenia 		GISAAA -,20,1993
oral
rat 		lowest published toxic dose: 36.8 mg/kg/20 day- intermittent Cardiac: Changes in heart weight

Blood: Changes in other cell count (unspecified) 		GISAAA -,20,1993
oral
rat 		lowest published toxic dose: 55.2 mg/kg/30 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		GISAAA -,20,1993


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5044;
Number of Industries 40;
Total Number of Facilities 6,993;
Number of Occupations 62;
Total Number of Employees Exposed 100,333;
Total Number of Female Employees Exposed 61,328


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as flavor and fragrance chemical
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-

Used as flavor and fragrance chemical

NIOSH PROFILE (ALDEHYDES), SRC, 4/78

NIOSH PROFILE (ALDEHYDES), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Human Data
   Natural Product
   Primary Irritant

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