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Ammonium, (2 - mercaptoethyl) trimethyl - , iodide, S - ester with O,O - diethylphosphorothioate

RTECS #: BR6985000

CAS #: 513-10-0

UPDATE: February 2008 MW: 383.26 MF: C9H23NO3PS•I


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. (2 - Mercaptoethyl) trimethylammonium iodide S - ester with O,O - diethyl phosphorothioate
  2. 2 - Diaethoxyphosphinyl - thioaethyl - trimethyl - ammonium - jodid (German)
  3. 2 - Diethoxy - phosphinylthioethyl - trimethylammonium iodide
  4. 217 MI
  5. Ammonium, (2 - (O,O - diethylphosphorothio) ethyl) trimethyl - , iodide
  6. Diethoxyphosphoryl - thiocholine iodide
  7. Echodide
  8. Echothiophate iodide
  9. Ecostigmini jodidum
  10. Ecothiopate iodide
  1. Ecothiophate iodide
  2. Ethanaminium, 2 - ( (diethoxyphosphinyl) thio) - N,N,N - trimethyl - , iodide
  3. N - (2 - (Diethoxyphosphinylthio) ethyl) trimethylammonium iodide
  4. O,O - Diethyl S - 2 - trimethylammonium ethylphosphonothiolate iodide
  5. Phospholine (the pharmaceutical)
  6. Phospholine iodide
  7. S - (2 - (N,N,N - Trimethylammonio) ethyl) O,O - diethylphosphorothiolate iodide
  8. S - (2 - Dimethylaminoethyl) - O.O - diethylphosphorothioate methiodide
  9. S - Ester of (2 - mercaptoethyl) trimethylammonium iodide with O,O - diethyl phosphorothioate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 140 µg/kg N/R TXAPA9 6,269,1964
intravenous
rabbit 		lethal dose (50 percent kill): 33 µg/kg Peripheral Nerve and Sensation: Fasciculations

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea 		JPETAB 118,420,1956
oral
mouse 		lethal dose (50 percent kill): 5,100 µg/kg N/R OYYAA2 1,168,1967
oral
rat 		lethal dose (50 percent kill): 174 µg/kg N/R APYPAY 32,507,1981
subcutaneous
mouse 		lethal dose (50 percent kill): 130 µg/kg N/R JMCMAR 19,810,1976
subcutaneous
mouse 		lowest published toxic dose: 0.1 mg/kg Peripheral Nerve and Sensation: Fasciculations

Eye: Miosis (pupilliary constriction)

Behavioral: Somnolence (general depressed activity) 		TXCYAC 233,60,2007
subcutaneous
rat 		lethal dose (50 percent kill): 174 µg/kg N/R APYPAY 32,507,1981
skin
rat 		lethal dose (50 percent kill): >100 mg/kg N/R APYPAY 31,279,1980
unreported route
rabbit 		lethal dose (50 percent kill): 250 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase AJOPAA 53,512,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 504 µg/kg/28 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		APYPAY 31,575,1980
subcutaneous
rat 		lowest published toxic dose: 348 µg/kg/17 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		APYPAY 32,507,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
CRTXB2 1(1),93,1971
TOXICOLOGY REVIEW
ENTOX* -,588,2005
TOXICOLOGY REVIEW
ENTOX* -,308,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3670;
Number of Industries 1;
Total Number of Facilities 20;
Number of Occupations 2;
Total Number of Employees Exposed 1,050;
Total Number of Female Employees Exposed 508


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
APYPAY Acta Physiologica Polonica. (Karger-Libri, POB CH-4009, Warszawa, Switzerland) V.1-41, 1950-90.
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

FDA-proprietary drug

RTECS Compound Description:
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