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Ammonium, (2 - hydroxypropyl) trimethyl - , chloride, carbamate

RTECS #: BR5425000

CAS #: 590-63-6

UPDATE: November 2005 MW: 196.71 MF: C7H17N2O2•Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. NIOSH DOCUMENTATION AND SURVEILLANCE:
  4. STATUS IN FEDERAL AGENCIES:
  5. REFERENCES:

SYNONYMS:

  1. (+ - ) - Bethanechol
  2. (2 - Hydroxypropyl) trimethylammonium chloride carbamate
  3. 1 - Propanaminium, 2 - ( (aminocarbonyl) oxy) - N,N,N - trimethyl - , chloride
  4. 2 - ( (Aminocarbonyl) oxy) - N,N,N - trimethyl - 1 - propanaminium chloride
  5. 2 - Carbamoyloxypropyltrimethylammonium chloride
  6. Besacholine
  7. Bethaine choline chloride
  8. Bethanechol chloride
  9. Carbaminoyl, beta - methylcholine chloride
  1. Carbamylmethylcholine chloride
  2. Duvoid
  3. Mechothane
  4. Myocholine
  5. Trimethyl (2 - carbamoyloxypropyl) ammonium chloride
  6. Urecholine
  7. Urecholine chloride
  8. Uro - Carb
  9. beta - Methylcholine chloride urethan


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
rat 		lowest published toxic dose: 20 µg/kg Brain and Coverings: Other degenerative changes

Behavioral: Fluid intake 		PSCHDL 167,174,2003
intramuscular
mouse 		lethal dose (50 percent kill): 192 mg/kg N/R NIIRDN 6,139,1982
intramuscular
rat 		lethal dose (50 percent kill): 220 mg/kg N/R NIIRDN 6,139,1982
intraperitoneal
mouse 		lethal dose (50 percent kill): 120 mg/kg N/R YAKUD5 9,759,1967
intravenous
guinea pig 		lowest published lethal dose: 13 mg/kg Vascular: BP lowering not characterized in autonomic section AIPTAK 106,245,1956
intravenous
guinea pig 		lowest published toxic dose: 1 mg/kg Liver: Change in gall bladder structure or function EJPHAZ 485,299,2004
intravenous
guinea pig 		lowest published toxic dose: 0.3 mg/kg Kidney, Ureter, and Bladder: Urine volume decreased or anuria EJPHAZ 494,225,2004
intravenous
mouse 		lethal dose (50 percent kill): 10 mg/kg N/R JPETAB 58,337,1936
intravenous
rat 		lethal dose (50 percent kill): 21 mg/kg N/R JPETAB 58,337,1936
oral
mouse 		lethal dose (50 percent kill): 250 mg/kg N/R JPETAB 58,337,1936
oral
rat 		lethal dose (50 percent kill): 1,500 mg/kg N/R JPETAB 58,337,1936
subcutaneous
human 		lowest published toxic dose: 130 mg/kg Skin: After systemic exposure: Dermatitis, other

Skin and Appendages: Other: Sweating 		34ZIAG -,130,1969
subcutaneous
man 		lowest published toxic dose: 1,071 µg/kg/3 day- intermittent Skin: After systemic exposure: Dermatitis, allergic

Skin and Appendages: Other: Sweating 		ARDEAC 95,499,1967
subcutaneous
mouse 		lethal dose (50 percent kill): 120 mg/kg N/R JPETAB 58,337,1936
subcutaneous
mouse 		lowest published toxic dose: 3 mg/kg Gastrointestinal: Alteration in gastric secretion PYTOEY 9,508,2002
subcutaneous
rat 		lethal dose (50 percent kill): 175 mg/kg N/R JPETAB 58,337,1936


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4038;
Number of Industries 2;
Total Number of Facilities 33;
Number of Occupations 9;
Total Number of Employees Exposed 3,625;
Total Number of Female Employees Exposed 1,425


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.82- 1960-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-
PYTOEY Phytomedicine. (Gustav Fischer Verlag, Postfach 720143, D-70577 Stuttgart, Germany) V.1- 1994-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used as a synthetic cholinergic drug

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Human Data

ALT CAS #: 21293-39-0
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