RTECS:BQ5870000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

Search NIOSH | NIOSH Home | NIOSH Topics | Site Index | Databases and Information Resources | NIOSH Products | Contact Us

Ammonium, ethyl (m - hydroxyphenyl) dimethyl - , chloride

RTECS #: BQ5870000

CAS #: 116-38-1

UPDATE: May 2005 MW: 201.72 MF: C₁₀H₁₆NO•Cl

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

Ammonium, dimethylethyl (m - hydroxyphenyl) - , chloride

Antirex

Benzenaminium, N - ethyl - 3 - hydroxy - N,N - dimethyl - , chloride (9CI)

Edrophonium chloride

Ethyl (m - hydroxyphenyl) dimethylammonium chloride

Tensilon

Tensilon chloride

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 30 mg/kg N/R PCJOAU 10,327,1976
intraspinal
rat lowest published toxic dose: 76.3 µg/kg Behavioral: Analgesia

Behavioral: Change in psychophysiological tests AANEAB 47,1079,2003
intravenous
human lowest published toxic dose: 0.2 mg/kg/15 minute Cardiac: EKG changes not diagnostic of above

Cardiac: Other changes JPETAB 300,112,2002
intravenous
human lowest published toxic dose: 1 mg/kg/25 minute Cardiac: EKG changes not diagnostic of above

Cardiac: Change in rate

Cardiac: Other changes JPETAB 300,112,2002
intravenous
mouse lethal dose (50 percent kill): 8,500 µg/kg N/R JPETAB 115,185,1955
subcutaneous
mouse lethal dose (50 percent kill): 52 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Muscle weakness JPETAB 123,121,1958

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5548;
Number of Industries 1;
Total Number of Facilities 17;
Number of Occupations 3;
Total Number of Employees Exposed 8,250;
Total Number of Female Employees Exposed 7,491

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

AANEAB Acta Anaesthesiologica Scandinavica. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.1- 1957-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-

FDA-proprietary drug

RTECS Compound Description:
Drug
Human Data

Click Here for Additional Information about RTECS

NIOSH Home | NIOSH Search | Site Index | Topic List | Contact Us