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Ammonium, ethyl (4 - (alpha - (p - (ethyl (m - sulfobenzyl) amino) phenyl) - 4 - hydroxy - 3 - sulfobenzylidene) - 2,5 - cyclohexadien - 1 - ylidene) (m - sulfobenzyl) - , hydroxide, inner salt, disodium salt

RTECS #: BQ4425000

CAS #: 2353-45-9

UPDATE: May 2008 MW: 810.91 MF: C37H36N2O10S3•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1724 Green
  2. Aizen Food Green No. 3
  3. C.I. 42053
  4. C.I. Food Green 3
  5. FD and C Green No. 3
  1. Fast Green FCF
  2. Food Green 3
  3. Solid Green FCF
  4. Zelen Stala FCF (Czech)
  5. Zelen potravinarska 3 (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster fibroblast 4 gm/L FCTOD7 22,623,1984
cytogenetic analysis hamster ovary 20 µmol/L/5 hour- continuous ENMUDM 1,27,1979
cytogenetic analysis hamster lung 2 gm/L GMCRDC 27,95,1981
cytogenetic analysis oral
mouse 		5,400 mg/kg/90 day- continuous CYTBAI 54,25,1988
cytogenetic analysis oral
mouse 		60 mg/kg/30 day- continuous CALEDQ 30,315,1986
DNA damage human mammary gland 260 mg/L/24 hour (-enzymatic activation step) MUREAV 588,47,2005
mutation in microorganisms Salmonella typhimurium 10 mg/plate (-enzymatic activation step) FCTOD7 22,623,1984
micronucleus test intraperitoneal
mouse 		100 mg/kg MUREAV 170,75,1986
sister chromatid exchange intraperitoneal
mouse 		10 mg/kg CALEDQ 52,33,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 5,925 mg/kg/48 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application 		JNCIAM 24,769,1960


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): >2 gm/kg N/R MEIEDD 11,618,1989


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 16,187,1978
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 16,187,1978
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
ARVPAX 14,127,1974
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3843;
Number of Industries 1;
Total Number of Facilities 15;
Number of Occupations 2;
Total Number of Employees Exposed 221
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M3843;
Number of Industries 4;
Total Number of Facilities 774;
Number of Occupations 11;
Total Number of Employees Exposed 9,107;
Total Number of Female Employees Exposed 6,209


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI.
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MEIEDD Merck Index. (Merck & Co., Inc., Rahway, NJ 07065) 10th ed. 1983. For publisher information, see 85KYAH.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-

Used as a colorant for food, drugs and cosmetics

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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