CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




Ammonium, (o - bromobenzyl) ethyldimethyl - , p - toluenesulfonate

RTECS #: BO9450000

CAS #: 61-75-6

UPDATE: March 1996 MW: 414.40 MF: C11H17BrN•C7H7O3S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. REFERENCES:

SYNONYMS:

  1. (o - Bromobenzyl) ethyldimethylammonium p - toluenesulfonate
  2. 2 - Bromo - N - ethyl - N,N - dimethylbenzenemethanaminium 4 - methylbenzenesulfonate
  3. ASL - 603
  4. Benzenemethanaminium, 2 - bromo - N - ethyl - N,N - dimethyl - , salt with 4 - methylbenzenesulfonic acid
  5. Bretylan
  6. Bretylate
  7. Bretylium p - toluenesulfonate
  1. Bretylium tosylate
  2. Bretylol
  3. Darenthin
  4. Darentin
  5. Dimethylethyl - o - bromobenzylammonium - p - toluenesulphonate
  6. N - Ethyl - N - o - bromobenzyl - N,N - dimethylammonium tosylate
  7. Ornid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
dog 		lethal dose (50 percent kill): 100 mg/kg N/R PBPSDY 2,148,1979
intramuscular
mouse 		lethal dose (50 percent kill): 64 mg/kg N/R PBPSDY 2,148,1979
intramuscular
rat 		lethal dose (50 percent kill): 84 mg/kg N/R PBPSDY 2,148,1979
intramuscular
rabbit 		lethal dose (50 percent kill): 160 mg/kg N/R PBPSDY 2,148,1979
intraperitoneal
mouse 		lethal dose (50 percent kill): 39 mg/kg N/R AIPTAK 155,69,1965
intraperitoneal
rat 		lethal dose (50 percent kill): 57 mg/kg N/R PHMGBN 21,256,1980
intravenous
dog 		lethal dose (50 percent kill): 43 mg/kg N/R PBPSDY 2,148,1979
intravenous
mouse 		lethal dose (50 percent kill): 14 mg/kg N/R PBPSDY 2,148,1979
intravenous
rat 		lethal dose (50 percent kill): 17 mg/kg N/R PBPSDY 2,148,1979
intravenous
rabbit 		lethal dose (50 percent kill): 30 mg/kg N/R PBPSDY 2,148,1979
intravenous
woman 		lowest published toxic dose: 81,500 µg/kg/15 minute- continuous Behavioral: Change in motor activity (specific assay)

Behavioral: Coma

Vascular: BP lowering not characterized in autonomic section 		AJEMEN 13,177,1995
oral
mouse 		lethal dose (50 percent kill): 400 mg/kg N/R BJPCAL 14,536,1959
subcutaneous
mouse 		lethal dose (50 percent kill): 72 mg/kg N/R BJPCAL 14,536,1959


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
PBPSDY 2,148,1979


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5621;
Number of Industries 1;
Total Number of Facilities 51;
Number of Occupations 1;
Total Number of Employees Exposed 1,056;
Total Number of Female Employees Exposed 657


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM.
PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977-
PHMGBN Pharmacology: International Journal of Experimental and Clinical Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1968-

Used as an anti-adrenergic and cardiac depressant (antiarrhythmic)

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Human Data

 Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  RTECS List |  Contact Us