The Registry of Toxic Effects of Chemical Substances

Adiponitrile

RTECS #: AV2625000

CAS #: 111-69-3

UPDATE: November 2007 MW: 108.16 MF: C6H8N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,4 - Dicyanobutane
  2. Adipic acid dinitrile
  3. Adipic acid nitrile
  4. Adipinsaeuredinitril (German)
  5. Adiponitril (ACGIH)
  1. Hexanedinitrile
  2. Hexanedioic acid, dinitrile
  3. Nitrile adipico (Italian)
  4. Tetramethylene cyanide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,120 mg/kg (6-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 7,33,1986
oral
rat 		lowest published toxic dose: 1,400 mg/kg (6-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) DCTODJ 27,123,2004


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 1,710 mg/m3/4 hour Ear: Change in acuity

Lung, Thorax, or Respiration: Other changes 		TOXID9 1,76,1981
inhalation
rat 		lethal concentration (50 percent kill): 1.71 gm/m3/4 hour N/R DCTODJ 27,123,2004
inhalation
rat 		lowest published lethal concentration: 0.83 gm/m3/4 hour Eye: Conjunctiva irritation

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		DCTODJ 27,123,2004
inhalation
rat 		lowest published lethal concentration: 0.83 gm/m3/4 hour Gastrointestinal: Changes in structure or function of salivary glands DCTODJ 27,123,2004
intraperitoneal
mouse 		lethal dose (50 percent kill): 40 mg/kg N/R NTIS** AD691-490
oral
cat 		lethal dose (50 percent kill): 25 mg/kg N/R ZAARAM 19,225,1969
oral
mouse 		lethal dose (50 percent kill): 172 mg/kg N/R ENTOX* -,49,2005
oral
rat 		lethal dose (50 percent kill): 100 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		DCTODJ 27,123,2004
oral
rat 		lethal dose (50 percent kill): 155 mg/kg N/R ENTOX* -,49,2005
oral
rabbit 		lethal dose (50 percent kill): 22 mg/kg N/R ENTOX* -,49,2005
subcutaneous
guinea pig 		lethal dose (50 percent kill): 50 mg/kg N/R ENTOX* -,49,2005
skin
rabbit 		lowest published lethal dose: 1 mg/kg N/R ZAARAM 19,225,1969
skin
rabbit 		lethal dose (50 percent kill): 2,134 mg/kg/24 hour N/R DCTODJ 27,123,2004
skin
rabbit 		lowest published lethal dose: 1,260 mg/kg/24 hour Behavioral: Sleep

Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal) 		DCTODJ 27,123,2004
skin
rabbit 		lowest published lethal dose: 1,260 mg/kg/24 hour Gastrointestinal: Nausea or vomiting DCTODJ 27,123,2004


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 500 mg/m3/4 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes 		DCTODJ 27,123,2004
inhalation
rat 		lowest published toxic concentration: 493 mg/m3/6 hour/4 week- intermittent Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JTEHD6 30,199,1990
inhalation
rat 		lowest published toxic concentration: 99 mg/m3/6 hour/13 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count 		JTEHD6 30,199,1990
inhalation
rat 		lowest published toxic concentration: 3,028 µg/m3/5 hour/26 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GTPZAB 25(9),64,1981
inhalation
rat 		lowest published toxic concentration: 30 mg/m3/2 week- intermittent Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		DCTODJ 27,123,2004
inhalation
rat 		lowest published toxic concentration: 100 mg/m3/2 week- intermittent Blood: Other changes DCTODJ 27,123,2004
inhalation
rat 		lowest published toxic concentration: 300 mg/m3/2 week- intermittent Blood: Changes in erythrocyte (RBC) count DCTODJ 27,123,2004
inhalation
rat 		lowest published toxic concentration: 500 mg/m3/4 week- intermittent Blood: Changes in spleen DCTODJ 27,123,2004
inhalation
rat 		lowest published toxic concentration: 100 mg/m3/22 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain DCTODJ 27,123,2004
oral
dog 		lowest published toxic dose: 350 mg/kg/244 day- continuous Gastrointestinal: Nausea or vomiting DCTODJ 27,123,2004
oral
rat 		lowest published toxic dose: 1,120 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field DCTODJ 27,123,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (skin) DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
DCTODJ 27,123,2004
TOXICOLOGY REVIEW
ENTOX* -,49,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (8.8 mg/m3), OCT 2002
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 8.8 mg/m3, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ADIPONITRILE-air 10 hour time-weighted average 4 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4253;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 2;
Total Number of Employees Exposed 478;
Total Number of Female Employees Exposed 41


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as very pure polar solvent or chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75.

Used as very pure polar solvent or chemical intermediate

NIOSH PROFILE (NITRILES), SRC, 10/77

RTECS Compound Description:
   Reproductive Effector

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