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Adenosine 5' - (tetrahydrogen triphosphate)

RTECS #: AU7416000

CAS #: 56-65-5

UPDATE: February 2008 MW: 507.22 MF: C10H16N5O13P3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 5' - ATP
  2. 9 - beta - D - Arabinofuranosyladenine 5' - triphosphate
  3. ATP
  4. ATP (nucleotide)
  5. Adenosine triphosphate
  6. Adenosine 5' - triphosphate
  7. Adenosine 5' - triphosphoric acid
  8. Adenylpyrophosphoric acid
  9. Adephos
  10. Adetol
  11. Adynol
  1. Ara - ATP
  2. Atipi
  3. Atriphos
  4. Glucobasin
  5. Myotriphos
  6. Striadyne
  7. Triadenyl
  8. Triphosaden
  9. Triphosphaden
  10. Triphosphoric acid adenosine ester


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition human lymphocyte 10 µmol/L CNREA8 42,2092,1982
DNA inhibition mouse leukocyte 2 µmol/L CHTHBK 27,61,1981
other mutation test systems human other cell types 10 µmol/L JIDEAE 65,52,1975


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 2,780 mg/kg N/R PCJOAU 20,160,1986
intrarenal
rabbit 		lowest published toxic dose: 0.8 mg/kg Vascular: BP lowering not characterized in autonomic section

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney 		BJPCBM 149,523,2006
intraspinal
rat 		lowest published toxic dose: 61 µg/kg Peripheral Nerve and Sensation: Sensory change involving segmental distribution JPETAB 303,66,2002
intravenous
rat 		lowest published toxic dose: 461.6 µg/kg/5 minute Vascular: BP lowering not characterized in autonomic section JPETAB 294,963,2000


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
human 		lowest published toxic dose: 129.6 mg/kg/30 hour- continuous Behavioral: Headache

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Nausea or vomiting 		JJIND8 92,321,2000
oral
rat 		lowest published toxic dose: 150 mg/kg/30 day- intermittent Biochemical: Metabolism (intermediary): Xanthine, purine or nucleotides including urate JPETAB 294,126,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
TPHSDY 23,504,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3124;
Number of Industries 1;
Total Number of Facilities 351;
Number of Occupations 8;
Total Number of Employees Exposed 6,576;
Total Number of Female Employees Exposed 5,259


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-

Used as a coenzyme and, in biochemical research, to inhibit enzymatic browning of food plants

RTECS Compound Description:
   Drug
   Mutagen
   Human Data
   Natural Product

ALT CAS #: 71800-44-7
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