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Adenosine

RTECS #: AU7175000

CAS #: 58-61-7

UPDATE: May 2009 MW: 267.28 MF: C10H13N5O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 6 - Amino - 9 - beta - D - ribofuranosyl - 9H - purine
  2. 9 - beta - D - Ribofuranosidoadenine
  3. 9 - beta - D - Ribofuranosyl - 9H - purin - 6 - amine
  4. Adenine riboside
  5. Adenocard
  6. Adenoscan
  7. Adenosin (German)
  8. Boniton
  1. Myocol
  2. Nucleocardyl
  3. Riboadenosine
  4. Sandesin
  5. USAF CB - 10
  6. beta - Adenosine
  7. beta - D - Adenosine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis intraperitoneal
mouse 		178 mg/kg NULSAK 17,199,1974
DNA damage mammal (species unspecified) lymphocyte 60 mmol/L PNASA6 48,686,1962
other mutation test systems human other cell types 100 µmol/L JIDEAE 65,52,1975
phage inhibition capacity Escherichia coli 1 gm/L ZAPOAK 12,583,1972


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
woman 		lowest published toxic dose: 0.24 mg/kg (175 day pregnant) Reproductive: Other effects to embryo or fetus AJEMEN 18,234,2000


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraarterial
dog 		lowest published toxic dose: 25 µg/kg Vascular: Measurement of regional blood flow JPETAB 303,117,2002
intraarterial
human 		lowest published toxic dose: 0.14 µg/kg Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney JCPCDT 35,758,2000
intraperitoneal
mouse 		lethal dose (50 percent kill): 500 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat 		lowest published toxic dose: 80 µg/kg Behavioral: Alteration of classical conditioning EURNE* 12,S66,2002
intraperitoneal
rat 		lowest published toxic dose: 80 µg/kg Brain and Coverings: Changes in surface EEG

Behavioral: Change in motor activity (specific assay) 		EURNE* 12,S67,2002
intrarenal
rabbit 		lowest published toxic dose: 6 µg/kg Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney BJPCBM 149,523,2006
intraspinal
rat 		lowest published toxic dose: 371.64 µg/kg Behavioral: Analgesia PHMCAA 75,157,2005
intravenous
human 		lowest published toxic dose: 200 µg/kg Autonomic Nervous System: Sympathomimetic

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation 		CEXPB9 27,676,2000
intravenous
human 		lowest published lethal dose: 0.9 mg/kg Cardiac: Pulse rate decreased with fall in BP

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression 		JEMME* 21,151,2001
intravenous
man 		lowest published toxic dose: 143 µg/kg/ intermittent Eye: Other eye effects

Behavioral: Headache 		MJAUAJ 162,389,1995
intravenous
man 		lowest published toxic dose: 50 µg/kg/1 minute- intermittent Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma HETOEA 13,263,1994
intravenous
man 		lowest published toxic dose: 257 µg/kg Cardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Cyanosis 		AJEMEN 11,249,1993
intravenous
man 		lowest published toxic dose: 171 µg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Cardiac: Pulse rate decreased with fall in BP 		AJEMEN 11,192,1993
intravenous
man 		lowest published toxic dose: 257 µg/kg/1 day- intermittent Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section 		AIMEAS 122,351,1995
intravenous
man 		lowest published toxic dose: 0.17 mg/kg Cardiac: Arrythmias (indlucing changes in conduction) SIMEJ* 48,e130,2007
intravenous
mouse 		lowest published toxic dose: 2 mg/kg Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney JPETAB 315,1150,2005
intravenous
mouse 		lowest published toxic dose: 20 mg/kg Vascular: BP lowering not characterized in autonomic section JPETAB 315,1150,2005
intravenous
rat 		lowest published toxic dose: 249.9 µg/kg/5 minute Vascular: BP lowering not characterized in autonomic section JPETAB 294,963,2000
intravenous
rat 		lowest published toxic dose: 1 mg/kg/1 hour Vascular: Measurement of regional blood flow JPETAB 294,1034,2000
intravenous
rat 		lowest published toxic dose: 12 mg/kg/12 hour Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		JPETAB 294,1034,2000
intravenous
woman 		lowest published toxic dose: 240 µg/kg Cardiac: Arrythmias (indlucing changes in conduction) AJEMEN 14,300,1996
intravenous
woman 		lowest published toxic dose: 360 µg/kg/1 hour- intermittent Cardiac: Pulse rate increased without fall in BP

Cardiac: Change in rate 		AJEMEN 10,326,1992
intravenous
woman 		lowest published toxic dose: 0.24 mg/kg Cardiac: Pulse rate increased without fall in BP AJEMEN 18,234,2000
oral
mouse 		lethal dose (50 percent kill): >20 gm/kg N/R YACHDS 8,45,1980
subcutaneous
mouse 		lethal dose (50 percent kill): 39.6 µg/kg N/R FATOAO 55,72,1992


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
rat 		lowest published toxic dose: 2,138 µg/kg/2 day- intermittent Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum NRTXDN 26,361,2005
intraperitoneal
rat 		lowest published toxic dose: 2,100 mg/kg/21 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain EJPHAZ 552,55,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
ARZNAD 7,24,1957
TOXICOLOGY REVIEW
TPHSDY 23,311,2002
TOXICOLOGY REVIEW
TPHSDY 24,409,2003
TOXICOLOGY REVIEW
DIMON* 24,507,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3937;
Number of Industries 2;
Total Number of Facilities 77;
Number of Occupations 2;
Total Number of Employees Exposed 556;
Total Number of Female Employees Exposed 387


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927-
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EURNE* European Neuropsychopharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Nov.1990-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
JCPCDT Journal of Cardiovascular Pharmacology. (Raven Press, 1140 Ave. of the Americas, New York, NY 10036) V.1- 1979-
JEMME* The Journal of emergency medicine (New York : Pergamon Press) V.1- 1983-
JIDEAE Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd., 71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958-
PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959-
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
SIMEJ*
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.1- 1960-

Used as a treatment for supraventricular tachycardias

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 46946-45-6
ALT CAS #: 46969-16-8
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