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Acrylic acid, triester with 2 - ethyl - 2 - (hydroxymethyl) - 1,3 - propanediol

RTECS #: AT4810000

CAS #: 15625-89-5

UPDATE: February 2003 MW: 296.35 MF: C15H20O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,3 - Propanediol, 2 - ethyl - 2 - (hydroxymethyl) - , triacrylate
  2. 2 - Ethyl - 2 - (hydroxymethyl) - 1,3 - propanediol triacrylate
  3. 2 - Propenoic acid, 2 - ethyl - 2 - ( ( (1 - oxo - 2 - propenyl) oxy) methyl) - 1,3 - propanediyl ester (9CI)
  4. Acrylic acid, 1,1,1 - (trihydroxymethyl) propane triester
  5. M 309
  6. MFM
  7. NK Ester A TMPT
  8. Ogumont T 200
  1. SR 351
  2. Saret 351
  3. Sartomer SR 351
  4. Setalux UV 2241
  5. TMPTA
  6. Trimethylolpropane triacrylate
  7. Viscoat 295


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg moderate JTEHD6 19,149,1986
skin
human 		1% AIHAAP 42(11),B53,1981
skin
human 		0.5%/48 hour JOCMA7 121,373,1985
skin
rabbit 		500 mg/24 hour moderate JTEHD6 19,149,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis mouse lymphocyte 600 µg/L MUTAEX 4,381,1989
micronucleus test mouse lymphocyte 650 µg/L MUTAEX 4,381,1989
mutation in mammalian somatic cells mouse lymphocyte 3,300 nmol/L EMMUEG 17,264,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 5 gm/kg (6-15 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		NTIS** OTS0571218


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 55 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		NTIS** OTS0555702
oral
rat 		lethal dose (50 percent kill): 5,190 µL/kg N/R TXAPA9 28,313,1974
skin
rabbit 		lethal dose (50 percent kill): 5,170 mg/kg N/R AIHAAP 42(11),B53,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
guinea pig 		lowest published toxic dose: 5 pph/12 week- intermittent Skin: After topical application: Cutaneous sensitization (experimental) CODEDG 9,55,1983
skin
rabbit 		lowest published toxic dose: 5 gm/kg/2 week- intermittent Skin: After systemic exposure: Dermatitis, other NTIS** OTS0555406


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3216;
Number of Industries 10;
Total Number of Facilities 388;
Number of Occupations 12;
Total Number of Employees Exposed 5,274;
Total Number of Female Employees Exposed 809


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in ultraviolet cured inks, coatings and adhesives
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (prechronic studies), October 2000
NTP Carcinogenesis studies; test completed (peer review), October 2000


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9, 1957-67. For publisher information, see:JJOMDZ
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in ultraviolet cured inks, coatings and adhesives

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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