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| UPDATE: May 2006 | MW: 258.30 | MF: C12H18O6 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
eye | rabbit
100 mg
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severe
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EPASR* 8EHQ-0981-0410
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skin | mouse
0.5%/14 day open irritation test
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moderate
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RTOPDW 37,54,2003
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skin | mouse
0.5%/14 day- intermittent open irritation test
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moderate
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RTOPDW 37,54,2003
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skin | rabbit
500 mg/24 hour
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severe
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EPASR* 8EHQ-0981-0410
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
|
ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
skin | mouse
lowest published toxic dose: 16 gm/kg/80 week- intermittent
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Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Blood: Lymphoma including Hodgkin's disease Skin and Appendages: Tumors
JTEHD6 19,149,1986
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
intraperitoneal | rat
lethal dose (50 percent kill): 125 mg/kg
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Behavioral: Altered sleep time (including change in righting reflex) | Behavioral: Tremor Behavioral: Ataxia
NTIS** OTS0543770
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oral | mouse
lethal dose (50 percent kill): 700 mg/kg
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N/R
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85GMAT -,115,1982
|
oral | rat
lethal dose (50 percent kill): 500 mg/kg
|
N/R
|
85GMAT -,115,1982
|
skin | rabbit
lethal dose (50 percent kill): 1,900 mg/kg
|
N/R
|
EPASR* 8EHQ-0981-0410
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
skin | rabbit
lowest published toxic dose: 2 gm/kg/2 week- intermittent
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Skin: After systemic exposure: Dermatitis, other
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NTIS** OTS0555406
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
N/R
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N/R
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N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
|
STANDARD or SURVEY
|
|
REFERENCE
National Occupational Hazard Survey 1974
|
National Occupational Hazard Survey 1974: Hazard Code: T1233; | Number of Industries 1; Total Number of Facilities 57; Number of Occupations 1; Total Number of Employees Exposed 57
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: T1233 |
 ;Number of Industries 3; Total Number of Facilities 150; Number of Occupations 3; Total Number of Employees Exposed 644; Total Number of Female Employees Exposed 134 | ||||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
85GMAT
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"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F.,
et al., Moscow, Centre of International Projects, GKNT, 1982
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EPASR*
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United States Environmental Protection Agency, Office of Pesticides and Toxic Substances.
(U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
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JTEHD6
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Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW,
Washington, DC 20005) V.1- 1975/76-
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NTIS**
|
National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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RTOPDW
|
Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN
55802) V.1- 1981-
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