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Acrylic acid, diester with triethylene glycol

RTECS #: AS8150000

CAS #: 1680-21-3

UPDATE: May 2006 MW: 258.30 MF: C12H18O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - Propenoic acid, 1,2 - ethanediylbis (oxy - 2,1 - ethanediyl) ester (9CI)
  1. Triethylene glycol diacrylate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe EPASR* 8EHQ-0981-0410
skin
mouse 		0.5%/14 day open irritation test moderate RTOPDW 37,54,2003
skin
mouse 		0.5%/14 day- intermittent open irritation test moderate RTOPDW 37,54,2003
skin
rabbit 		500 mg/24 hour severe EPASR* 8EHQ-0981-0410


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 16 gm/kg/80 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Lymphoma including Hodgkin's disease

Skin and Appendages: Tumors 		JTEHD6 19,149,1986


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 125 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Behavioral: Ataxia 		NTIS** OTS0543770
oral
mouse 		lethal dose (50 percent kill): 700 mg/kg N/R 85GMAT -,115,1982
oral
rat 		lethal dose (50 percent kill): 500 mg/kg N/R 85GMAT -,115,1982
skin
rabbit 		lethal dose (50 percent kill): 1,900 mg/kg N/R EPASR* 8EHQ-0981-0410


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		lowest published toxic dose: 2 gm/kg/2 week- intermittent Skin: After systemic exposure: Dermatitis, other NTIS** OTS0555406


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T1233;
Number of Industries 1;
Total Number of Facilities 57;
Number of Occupations 1;
Total Number of Employees Exposed 57
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T1233;
Number of Industries 3;
Total Number of Facilities 150;
Number of Occupations 3;
Total Number of Employees Exposed 644;
Total Number of Female Employees Exposed 134


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RTOPDW Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981-

RTECS Compound Description:
   Tumorigen
   Primary Irritant

Click Here for Additional Information about RTECS

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