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Acrylamide, N,N' - methylenebis -

RTECS #: AS3678000

CAS #: 110-26-9

UPDATE: February 2007 MW: 154.19 MF: C7H10N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - Propenamide, N,N' - methylenebis -
  2. Methylenebisacrylamide
  3. N,N' - Methylenebis (2 - propenamide)
  4. N,N' - Methylenebis (acrylamide)
  1. N,N' - Methylenebisacrylamide
  2. N,N' - Methylenediacrylamide
  3. N,N' - Methylidenebisacrylamide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
dominant lethal test intraperitoneal
mouse 		225 mg/kg MUREAV 229,161,1990
mutation in microorganisms Salmonella typhimurium 1 mg/plate (-enzymatic activation step) EMMUEG 11(Suppl 12),1,1988
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		600 ppm EMMUEG 23,208,1994
heritable translocation test intraperitoneal
mouse 		450 mg/kg/5 day- continuous MUREAV 229,161,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 225 mg/kg (1 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		MUREAV 229,161,1990
oral
mouse 		lowest published toxic dose: 3,208 mg/kg (16 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct ARTODN 47,179,1981
oral
mouse 		lowest published toxic dose: 360 mg/kg (6-17 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		NTIS** PB92-177781
oral
mouse 		lowest published toxic dose: 50 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) ARTODN 62,54,1988
oral
mouse 		lowest published toxic dose: 4.7 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system NTIS** #PB93160976
oral
mouse 		lowest published toxic dose: 164.5 mg/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) NTIS** #PB93160976
oral
mouse 		lowest published toxic dose: 1.6 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB93160976
oral
mouse 		lowest published toxic dose: 1,758 mg/kg (27 week male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NTIS** #PB93160976
oral
mouse 		lowest published toxic dose: 1,758 mg/kg (27 week prior to copulation) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB93160976
oral
mouse 		lowest published toxic dose: 1,758 mg/kg (multigenerations) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) NTIS** #PB93160976
oral
mouse 		lowest published toxic dose: 325.5 mg/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB93160976
oral
mouse 		lowest published toxic dose: 120 mg/kg (6-17 day pregnant) Reproductive: Other developmental abnormalities NTPTR* TER-90008
oral
mouse 		lowest published toxic dose: 360 mg/kg (6-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTPTR* TER-90008


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration : >41 ppm/6 hour Lung, Thorax, or Respiration: Acute pulmonary edema ATDAEI 1,111,1990
inhalation
mouse 		lethal concentration : >41 ppm/6 hour Lung, Thorax, or Respiration: Acute pulmonary edema ATDAEI 1,111,1990
inhalation
rat 		lethal concentration : >41 ppm/6 hour Lung, Thorax, or Respiration: Acute pulmonary edema ATDAEI 1,111,1990
oral
mouse 		lethal dose (50 percent kill): 380 mg/kg N/R ATDAEI 1,111,1990
oral
rat 		lethal dose (50 percent kill): 390 mg/kg Eye: Other eye effects

Behavioral: Tremor

Lung, Thorax, or Respiration: Other changes 		ATDAEI 1,111,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 3,259 mg/kg/13 week- intermittent Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Food intake (animal)

Musculoskeletal: Other changes 		NTIS** OTS0571723
oral
mouse 		lowest published toxic dose: 3,206 mg/kg/8 week- intermittent Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Related to Chronic Data: Changes in testicular weight 		ARTODN 47,179,1981
oral
mouse 		lowest published toxic dose: 888.3 mg/kg/27 week- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct NTIS** #PB93160976
oral
mouse 		lowest published toxic dose: 21 mg/kg/7 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* TER-90008
oral
mouse 		lowest published toxic dose: 120 mg/kg/12 day- intermittent Liver: Changes in liver weight NTPTR* TER-90008
oral
mouse 		lowest published toxic dose: 120 mg/kg/12 day- intermittent Related to Chronic Data: Changes in uterine weight NTPTR* TER-90008


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83963;
Number of Industries 4;
Total Number of Facilities 199;
Number of Occupations 5;
Total Number of Employees Exposed 2,098
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83963;
Number of Industries 2;
Total Number of Facilities 10;
Number of Occupations 3;
Total Number of Employees Exposed 66;
Total Number of Female Employees Exposed 35


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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