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Acridinium, 3,6 - diamino - 10 - methyl - , chloride mixed with 3,6 - acridinediamine

RTECS #: AR9660000

CAS #: 8048-52-0

UPDATE: June 2000 MW: 469.03 MF: C14H14N3•Cl•C13H11N3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 2,8 - Diamino - 10 - methylacridinium chloride mixture with 2,8 - diaminoacridine
  2. 3,6 - Diaminoacridine mixture with 3,6 - diamino - 10 - methylacridinium chloride
  3. 3,6 - Diamino - 10 - methylacridinium chloride mixture with 3,6 - acridinediamine
  4. Angiflan
  5. Assiflavine
  6. Bialflavina
  7. Bioacridin
  8. Bovoflavin
  9. Buroflavin
  10. Choliflavin
  11. Diacrid
  12. Flavacridinum hydrochloricum
  13. Flavine
  14. Flavinetten
  15. Flavioform
  1. Flavipin
  2. Flavisept
  3. Glyco - flavine
  4. Gonacin
  5. Gonacrine
  6. Isravin
  7. Mediflavin
  8. Panflavin
  9. Pantonsiletten
  10. Tolivalin
  11. Trachosept
  12. Tripla - etilo
  13. Vetaflavin
  14. Xanthacridinum
  15. Zoriflavin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 100 µg/L MUREAV 444,463,1999
dominant lethal test intraperitoneal
mouse 		50 mg/kg DMWOAX 92,2315,1967
DNA damage mouse mammary gland 100 nmol/L JOBIAO 84,145,1978
unscheduled DNA synthesis rat liver 5 µmol/L ENMUDM 3,11,1981
mutation in microorganisms Aspergillus nidulans 10 mg/L (-enzymatic activation step) GENRA8 7,207,1966
mutation in microorganisms Salmonella typhimurium 40 µmol/L (+enzymatic activation step) ENMUDM 3,11,1981
mutation in microorganisms Saccharomyes cerevisiae 25 µmol/L (-enzymatic activation step) JSPMAW 1,449,1973
mutation in mammalian somatic cells mouse lymphocyte 500 µg/L MUREAV 125,291,1984
morphological transform hamster kidney 25 mg/L TXCYAC 19,55,1981
sister chromatid exchange human lymphocyte 100 µg/L MUREAV 444,463,1999


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 160 mg/kg/60 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		SEMEAS 159,778,1952


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 13,31,1977
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 13,31,1977
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1531;
Number of Industries 1;
Total Number of Facilities 10;
Number of Occupations 1;
Total Number of Employees Exposed 40;
Total Number of Female Employees Exposed 10


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-forward mutation
EPA GENETOX PROGRAM 1988, Positive: In vitro mammalian nonhuman micronucleus
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-mouse; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte; Host-mediated assay
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; S cerevisiae gene conversion


REFERENCES:

CODEN
REFERENCE
DMWOAX Deutsche Medizinische Wochenschrift. (Stuttgart, Fed. Rep. Ger.) V.1-104, 1875-1979.
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GENRA8 Genetical Research. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.1- 1960-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JOBIAO Journal of Biochemistry (Tokyo). (Japanese Biochemical Soc., c/o Japan Academic Soc. Center, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.1- 1922-
JSPMAW Journal of Supramolecular Structure. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
SEMEAS Semana Medica. (Sociedad Argentina de Gastroenterologica, Santa Fe 1171, Buenos Aires, Argentina) V.1- 1894-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a topical antiseptic and as a drug for the treatment of gonorrhoea

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Human Data

ALT CAS #: 51555-26-1
ALT CAS #: 53307-10-1
 Click Here for Additional Information about RTECS

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