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Acridine, 3,6 - diamino -

RTECS #: AR8670000

CAS #: 92-62-6

UPDATE: May 2006 MW: 209.27 MF: C13H11N3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 2,8 - Diaminoacridine (European)
  2. 2,8 - Diaminoacridinium
  3. 3,6 - Acridinediamine (9CI)
  4. 3,6 - Diaminoacridine
  5. 3,6 - Diaminoacridinium
  1. 3,7 - Diamino - 5 - azaanthracene
  2. Isoflav base
  3. Proflavin
  4. Proflavine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 1 mg/L JNCIAM 59,289,1977
cytogenetic analysis hamster fibroblast 4 µmol/L ECREAL 85,239,1974
cytogenetic analysis human HeLa cell 1 mg/L/1 hour ECREAL 39,296,1965
DNA damage hamster lung 100 µmol/L/5 minute MUREAV 503,21,2002
DNA damage mammal (species unspecified) lymphocyte 13,500 nmol/L ZEKBAI 67,127,1965
DNA damage mouse Ascites tumor 48 µmol/L BBACAQ 374,96,1974
DNA damage salmon sperm 100 mmol ABBIA4 120,292,1967
DNA inhibition human fibroblast 10 µmol/L MUREAV 183,89,1987
DNA inhibition intraperitoneal
mouse 		100 mg/kg MUREAV 46,305,1977
DNA inhibition mouse embryo 1 µmol/L MOPMA3 21,739,1982
DNA repair Escherichia coli 1 mg/plate MUREAV 54,101,1978
unscheduled DNA synthesis rat liver 1 µmol/L ENMUDM 3,11,1981
mutation in microorganisms Escherichia coli 10 µg/plate (-enzymatic activation step) MUREAV 25,187,1974
mutation in microorganisms other microorganisms 4 mg/L (-enzymatic activation step) JMOBAK 3,762,1961
mutation in microorganisms other microorganisms 7,500 µg/L (-enzymatic activation step) JOVIAM 16,1000,1975
mutation in microorganisms other microorganisms 10 µmol/L (-enzymatic activation step) GENTAE 90,1,1978
mutation in microorganisms other microorganisms 5 mg/L (-enzymatic activation step) VIRLAX 37,335,1969
mutation in microorganisms Salmonella typhimurium 1 µg/plate (+enzymatic activation step) CPBTAL 35,792,1987
mutation in microorganisms Saccharomyes cerevisiae 25 µmol/L (-enzymatic activation step) MUREAV 82,87,1981
micronucleus test hamster lung 9 µmol/L/3 hour (-enzymatic activation step) MUREAV 503,21,2002
gene conversion and mitotic recombination Saccharomyes cerevisiae 1 µmol/L MGGEAE 144,131,1976
morphological transform mouse embryo 1 µmol/L MOPMA3 21,739,1982
morphological transform rat embryo 370 ng/plate JJATDK 1,190,1981
other mutation test systems mouse embryo 1 µmol/L MOPMA3 21,739,1982
sister chromatid exchange hamster lung 1 mg/L JNCIAM 59,289,1977
sister chromatid exchange hamster ovary 20 µg/L ENMUDM 4,65,1982
sister chromatid exchange hamster fibroblast 1 µmol/L ECREAL 85,239,1974
specific locus test intraperitoneal
silkworm 		50 mg MUREAV 22,295,1974


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 50 mg/kg N/R CHTHBK 16,371,1971
intravenous
cat 		lowest published lethal dose: 11,111 µg/kg Olfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Other changes 		LANCAO 196,838,1919
oral
mouse 		lethal dose (50 percent kill): >1 gm/kg N/R JMCMAR 18,320,1975
subcutaneous
mouse 		lethal dose (50 percent kill): 140 mg/kg N/R BJEPA5 28,1,1947


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 24,195,1980
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 24,195,1980
TOXICOLOGY REVIEW
EMMUEG 45,100,2005
TOXICOLOGY REVIEW
EMMUEG 44,163,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6466;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 2;
Total Number of Employees Exposed 628;
Total Number of Female Employees Exposed 621


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Positive: L5178Y cells in vitro-TK test; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: In vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
EPA GENETOX PROGRAM 1988, Inconclusive: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951-
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947-
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1920-
CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968-
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958-
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264) V.1- 1916-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
JMOBAK Journal of Molecular Biology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JOVIAM Journal of Virology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1967-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
MOPMA3 Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1965-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
VIRLAX Virology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1955-
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7.

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Human Data

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