RTECS:AR7601000 The Registry of Toxic Effects of Chemical Substances

Acridine, 3,6 - bis (dimethylamino) - , monohydrochloride

RTECS #: AR7601000

CAS #: 65-61-2

UPDATE: May 2006 MW: 301.85 MF: C₁₇H₁₉N₃•ClH

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

3,6 - Acridinediamine, N,N,N',N' - tetramethyl - , monohydrochloride

3,6 - Bis (dimethylamino) acridine hydrochloride

Acridine Orange NO

Acridine Orange

Acridine Orange N

Acridine Orange NS

Acridine Orange R

Basic Orange 14

Basic Orange 3RN

C.I. 46005

C.I. Basic Orange 14

Rhoduline Orange NO

Sumitomo Acridine Orange NO

Sumitomo Acridine Orange RK conc.

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
DNA adduct mammal (species unspecified) lymphocyte 10 pph BIPMAA 11,2537,1972
DNA adduct salmon sperm 40 nmol/L BBRCA9 40,1239,1970
DNA damage mouse Ascites tumor 20 µmol/L BBACAQ 374,96,1974
micronucleus test multiple
non-mammalian species 700 nmol/L MUTAEX 4,17,1989
morphological transform hamster embryo 2,500 µg/L AETODY 1,241,1980
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 35,300,2000
other mutation test systems Escherichia coli 10 µmol/L MUREAV 203,81,1988
phage inhibition capacity Escherichia coli 9,400 ng/well MUREAV 260,349,1991
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 5,000 ppm MUREAV 121,199,1983

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 578,88,2005

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3803;
Number of Industries 1;
Total Number of Facilities 29;
Number of Occupations 3;
Total Number of Employees Exposed 625;
Total Number of Female Employees Exposed 403
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X8883;
Number of Industries 1;
Total Number of Facilities 10;
Number of Occupations 1;
Total Number of Employees Exposed 114;
Total Number of Female Employees Exposed 31

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: Mouse spot test; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: S cerevisiae-forward mutation
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN
REFERENCE

AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980-
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947-
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
BIPMAA Biopolymers. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1963-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-

RTECS Compound Description:
Mutagen

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SYNONYMS:
3,6 - Acridinediamine, N,N,N',N' - tetramethyl - , monohydrochloride 3,6 - Bis (dimethylamino) acridine hydrochloride Acridine Orange NO Acridine Orange Acridine Orange N Acridine Orange NS Acridine Orange R	Basic Orange 14 Basic Orange 3RN C.I. 46005 C.I. Basic Orange 14 Rhoduline Orange NO Sumitomo Acridine Orange NO Sumitomo Acridine Orange RK conc.

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
DNA adduct	mammal (species unspecified) lymphocyte	10 pph	BIPMAA 11,2537,1972
DNA adduct	salmon sperm	40 nmol/L	BBRCA9 40,1239,1970
DNA damage	mouse Ascites tumor	20 µmol/L	BBACAQ 374,96,1974
micronucleus test	multiple non-mammalian species	700 nmol/L	MUTAEX 4,17,1989
morphological transform	hamster embryo	2,500 µg/L	AETODY 1,241,1980
morphological transform	mouse fibroblast	0.1 mg/L/21 day (-enzymatic activation step)	EMMUEG 35,300,2000
other mutation test systems	Escherichia coli	10 µmol/L	MUREAV 203,81,1988
phage inhibition capacity	Escherichia coli	9,400 ng/well	MUREAV 260,349,1991
sex chromosome loss and nondisjunction	oral Drosophila melanogaster	5,000 ppm	MUREAV 121,199,1983

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		MUREAV 578,88,2005

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X3803; Number of Industries 1; Total Number of Facilities 29; Number of Occupations 3; Total Number of Employees Exposed 625; Total Number of Female Employees Exposed 403
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X8883; Number of Industries 1; Total Number of Facilities 10; Number of Occupations 1; Total Number of Employees Exposed 114; Total Number of Female Employees Exposed 31

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: Mouse spot test; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: S cerevisiae-forward mutation
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN	REFERENCE
AETODY	Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980-
BBACAQ	Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947-
BBRCA9	Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
BIPMAA	Biopolymers. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1963-
EMMUEG	Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX	Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-