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Acetic acid, (2,4 - dichlorophenoxy) - , compd. with dimethylamine (1:1)

RTECS #: AG8400000

CAS #: 2008-39-1

UPDATE: February 2008 MW: 386.24 MF: C18H6Cl2O3•C2H7N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. REFERENCES:

SYNONYMS:

  1. (2,4 - Dichlorophenoxy) acetic acid dimethylamine
  2. 2,4 - D DMA
  3. 2,4 - D acetate
  4. 2,4 - D amine
  5. 2,4 - D amine salt
  6. 2,4 - D dimethylamine salt
  7. Acetic acid, (2,4'dichlorophenoxy) - , compd. with N - methylmethanamine (1:1) (9CI)
  8. Aminol
  9. Aminol (herbicide)
  10. Aminoprelik 39
  11. Bladex G
  12. Brabant 2,4 - D amine
  13. D 50 (pesticide)
  14. Demise
  1. Dikamin D
  2. Dimethylamine, (2,4 - dichlorophenoxy) acetate
  3. Dimethylammonium 2,4 - dichlorophenoxyacetate
  4. Dimethylammonium salt of 2,4 - dichlorophenoxyacetic acid
  5. Formula 40
  6. Hormin
  7. Monosan
  8. Phordene
  9. Reed amine 400
  10. Shirweed 500
  11. Spraygraze
  12. U - 46 D - Fluid
  13. Weedar 96


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 500 µmol/L MUTAEX 1,241,1986
cytogenetic analysis oral
mouse 		14 mg/kg/15 day- continuous GISAAA 57(2),66,1992
dominant lethal test multiple
non-mammalian species 		50 mg/L/10 day- continuous MUREAV 611,83,2006
specific locus test multiple
non-mammalian species 		0.1 gm/L/10 day- continuous MUREAV 611,83,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 3 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 22,14,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
chicken 		lethal dose (50 percent kill): 420 mg/kg Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		POSCAL 77,509,1998
oral
rat 		lethal dose (50 percent kill): 625 mg/kg Behavioral: Somnolence (general depressed activity)

Kidney, Ureter, and Bladder: Urine volume increased

Lung, Thorax, or Respiration: Other changes 		GISAAA 36(11),33,1971
oral
rat 		lowest published toxic dose: 22.8 mg/kg N/R CMSHAF 43,801,2001
oral
rat 		lowest published toxic dose: 22.8 mg/kg Blood: Other hemolysis with or without anemia

Blood: Changes in other cell count (unspecified) 		CMSHAF 43,801,2001
skin
rabbit 		lethal dose (50 percent kill): 2,115 mg/kg N/R FMCHA2 -,C98,1991
unreported route
mouse 		lethal dose (50 percent kill): 300 mg/kg N/R HYSAAV 31(7-9),383,1966
unreported route
rat 		lethal dose (50 percent kill): 1 gm/kg N/R HYSAAV 31(7-9),383,1966


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 1,193 mg/kg/13 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain FAATDF 29,78,1996
oral
rat 		lowest published toxic dose: 600 µL/kg/30 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Biochemical: Metabolism (intermediary): Other proteins 		VHTODE 38,348,1996
oral
rat 		lowest published toxic dose: 10,800 mg/kg/72 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		GISAAA 36(11),33,1971
oral
rat 		lowest published toxic dose: 27,300 mg/kg/13 week- continuous Endocrine: Changes in thyroid weight

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 33,161,1996
oral
rat 		lowest published toxic dose: 3,600 µL/kg/26 week- continuous Endocrine: Hypoglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		VHTODE 38,348,1996


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,70,1998
Occupational Exposure Limit - SWITZERLAND MAK- week 1 mg/m3,KZG- week 8 mg/m3, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2199;
Number of Industries 1;
Total Number of Facilities 166;
Number of Occupations 2;
Total Number of Employees Exposed 5,300


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
POSCAL Poultry Science. (Poultry Science Assoc., Inc., 309 W. Clark St., Champaign, IL 61820) V.1- 1921-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-

Used to control broadleaf weeds in corn, sorghum, small grains, pastures and turfs

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 59644-62-1
ALT CAS #: 64296-19-1
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