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Acetamide, N - (5 - sulfamoyl - 1,3,4 - thiadiazol - 2 - yl) - , monosodium salt

RTECS #: AC8400000

CAS #: 1424-27-7

UPDATE: June 2000 MW: 244.24 MF: C4H5N4O3S2•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. Acetamide, N - (5 - (aminosulfonyl) - 1,3,4 - thiadiazol - 2 - yl) - , monosodium salt (9CI)
  2. Acetazolamide sodium salt
  3. Acetazolamide sodium
  1. Diamox sodium
  2. Sodium acetazolamide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
hamster 		lowest published toxic dose: 300 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 4,95,1971
intraperitoneal
hamster 		lowest published toxic dose: 600 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TJADAB 4,95,1971
intraperitoneal
mouse 		lowest published toxic dose: 1,500 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TJADAB 60,137,1999
intraperitoneal
rat 		lowest published toxic dose: 1 gm/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 1,51,1968
intravaginal
hamster 		lowest published toxic dose: 110 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 7,209,1973
oral
mouse 		lowest published toxic dose: 850 mg/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 28,355,1983
subcutaneous
mouse 		lowest published toxic dose: 1 gm/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 10,221,1974
subcutaneous
mouse 		lowest published toxic dose: 200 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) TJADAB 27,51,1983
subcutaneous
mouse 		lowest published toxic dose: 1 gm/kg (8 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		TJADAB 28,45,1983
subcutaneous
mouse 		lowest published toxic dose: 3 gm/kg (9-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death TJADAB 28,45,1983
subcutaneous
mouse 		lowest published toxic dose: 200 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 28,45,1983
subcutaneous
rat 		lowest published toxic dose: 1 gm/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 1,51,1968
subcutaneous
rabbit 		lowest published toxic dose: 1,500 mg/kg (13 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) 		TJADAB 15,199,1977
subcutaneous
rabbit 		lowest published toxic dose: 1,500 mg/kg (13 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TJADAB 15,199,1977


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
dog 		lethal dose : >2 gm/kg N/R JHHBAI 95,199,1954
intravenous
mouse 		lethal dose (50 percent kill): 3 gm/kg N/R JHHBAI 95,199,1954
oral
rat 		lethal dose : >1 gm/kg N/R JHHBAI 95,199,1954
subcutaneous
guinea pig 		lowest published lethal dose: 1,500 mg/kg N/R JHHBAI 95,199,1954
subcutaneous
rat 		lowest published lethal dose: 3 gm/kg N/R JHHBAI 95,199,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
dog 		lowest published toxic dose: 1 gm/kg/10 day- intermittent Nutritional and Gross Metabolic: Changes in: Na

Nutritional and Gross Metabolic: Changes in: K 		JHHBAI 95,199,1954


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5616;
Number of Industries 1;
Total Number of Facilities 17;
Number of Occupations 1;
Total Number of Employees Exposed 223;
Total Number of Female Employees Exposed 137


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
JHHBAI Bulletin of the Johns Hopkins Hospital. (Baltimore, MD) V.1-119, 1889-1966. For publisher information, see JHMJAX.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Reproductive Effector

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