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Acetamide, N - (4 - ( (2 - hydroxy - 5 - methylphenyl) azo) phenyl) -

RTECS #: AC3662000

CAS #: 2832-40-8

UPDATE: November 2007 MW: 269.33 MF: C15H15N3O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 4' - ( (6 - Hydroxy - m - tolyl) azo) acetanilide
  2. 4 - Acetamido - 2' - hydroxy - 5' - methylazobenzene
  3. Acetamine Yellow CG
  4. Acetate Fast Yellow G
  5. Acetoquinone Light Yellow
  6. Acetoquinone Light Yellow 4JLZ
  7. Altco Sperse Fast Yellow GFN New
  8. Amacel Yellow G
  9. Artisil Direct Yellow G
  10. Artisil Yellow G
  11. Artisil Yellow 2GN
  12. C.I. 11855
  13. C.I. 3/11855
  14. C.I. Disperse Yellow 3
  15. C.I. Solvent Yellow 77
  16. CI Solvent Yellow 92
  17. CI Solvent Yellow 99
  18. Calcosyn Yellow GC
  19. Calcosyn Yellow GCN
  20. Celliton Discharge Yellow GL
  21. Celliton Fast Yellow G
  22. Celliton Fast Yellow GA
  23. Celliton Fast Yellow GA - CF
  24. Celliton Yellow G
  25. Celutate Yellow GH
  26. Cibacete Yellow GBA
  27. Cibacet Yellow GBA
  28. Cibacet Yellow 2GC
  29. Cilla Fast Yellow G
  30. Diacelliton Fast Yellow G
  31. Disperse Yellow 3
  32. Disperse Yellow G
  33. Disperse Yellow Z
  34. Dispersive Yellow 3T
  35. Dispersol Fast Yellow G
  36. Dispersol Printing Yellow G
  37. Dispersol Yellow A - G
  38. Disperse Fast Yellow G
  39. Durgacet Yellow G
  40. Durosperse Yellow G
  41. Eastone Yellow GN
  42. Esteroquinone Light Yellow 4JL
  43. Estone Yellow GN
  44. Fenacet Fast Yellow G
  45. Fenacet Yellow G
  46. Genacron Yellow G
  1. Hispacet Fast Yellow G
  2. Hisperse Yellow G
  3. Interchem Acetate Yellow G
  4. Interchem Disperse Yellow GH
  5. Intraperse Yellow GBA
  6. Intrasperse Yellow GBA Extra
  7. Kayalon Fast Yellow G
  8. Kayaset Yellow G
  9. Kca Acetate Fast Yellow G
  10. Microsetile Yellow GR
  11. Miketon Fast Yellow G
  12. N - (4 - ( (2 - Hydroxy - 5 - methylphenyl) azo) phenyl) acetamide
  13. NCI - C53781
  14. Nacelan Fast Yellow CG
  15. Novalon Yellow 2GN
  16. Nyloquinone Light Yellow 4JL
  17. Nyloquinone Yellow 4J
  18. Ostacet Yellow P2G
  19. Palacet Yellow GN
  20. Palanil Yellow G
  21. Pamacel Yellow G - 3
  22. Perliton Yellow G
  23. Reliton Yellow C
  24. Resiren Yellow TG
  25. Safaritone Yellow G
  26. Samaron Yellow PA3
  27. Serinyl Hosiery Yellow GD
  28. Seriplas Yellow GD
  29. Serisol Fast Yellow GD
  30. Setacyl Yellow G
  31. Setacyl Yellow 2GN
  32. Setacyl Yellow P - 2GL
  33. Silotras Yellow TSG
  34. Supracet Fast Yellow G
  35. Synten Yellow 2G
  36. Synton Yellow 2G
  37. Terasil Yellow GBA Extra
  38. Terasil Yellow 2GC
  39. Tertranese Yellow N - 2GL
  40. Tuladisperse Fast Yellow 2G
  41. Vonteryl Yellow G
  42. Vonteryl Yellow R
  43. Yellow reliton G
  44. Yellow Z
  45. Zlut disperzni 3 (Czech)
  46. Zlut rozpoustedlova 77 (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis parenteral
frog 		28 gm/L CYTBAI 25,175,1979
DNA damage oral
mouse 		2 gm/kg MUREAV 465,11,2000
mutation in microorganisms mouse lymphocyte 10 mg/L (+enzymatic activation step) EMMUEG 12,85,1988
mutation in microorganisms Salmonella typhimurium 10 µg/plate (+/-enzymatic activation step) SCIEAS 236,933,1987
mutation in microorganisms Salmonella typhimurium 50 mg/L/2 hour (-enzymatic activation step) EMMUEG 44,329,2004
mutation in microorganisms Salmonella typhimurium 100 mg/L/2 hour (+enzymatic activation step) EMMUEG 44,329,2004
sister chromatid exchange hamster ovary 5 mg/L SCIEAS 236,933,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 433 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		NTPTR* NTP-TR-222,1982
oral
mouse 		toxic dose : 216 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma 		NTPTR* NTP-TR-222,1982
oral
mouse 		lowest published toxic dose: 432,600 mg/kg/103 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		NTIS** PB82-230061
oral
mouse 		lowest published toxic dose: 432,600 mg/kg/103 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Blood: Lymphoma including Hodgkin's disease 		NTIS** PB82-230061
oral
rat 		lowest published toxic dose: 180 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Leukemia 		NTPTR* NTP-TR-222,1982
oral
rat 		toxic dose : 216 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Leukemia 		NTPTR* NTP-TR-222,1982
oral
rat 		lowest published toxic dose: 432,600 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** PB82-230061


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 8,080 mg/kg Behavioral: Somnolence (general depressed activity)

Cardiac: Other changes

Lung, Thorax, or Respiration: Dyspnea 		GISAAA 53(10),92,1988
intraperitoneal
rat 		lethal dose (50 percent kill): 8,190 mg/kg Behavioral: Somnolence (general depressed activity)

Cardiac: Other changes

Lung, Thorax, or Respiration: Dyspnea 		GISAAA 53(10),92,1988
oral
mouse 		lethal dose : >14 mg/kg N/R GISAAA 53(10),93,1988
oral
rat 		lethal dose : >14 mg/kg N/R GISAAA 53(10),93,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 168 gm/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-222,1982
oral
mouse 		lowest published toxic dose: 109 gm/kg/13 week- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen 		NTIS** NTP-TR-222,1982
oral
rat 		lowest published toxic dose: 35 gm/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-222,1982
oral
rat 		lowest published toxic dose: 91 gm/kg/13 week- continuous Endocrine: Other changes

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** NTP-TR-222,1982
skin
human 		lowest published toxic concentration: 1 pph/72 hour- continuous Skin: After topical application: Dermatitis, allergic AJCDE* 13,101,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 48,149,1990
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 8,97,1975
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 8,97,1975
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 48,149,1990
TOXICOLOGY REVIEW
JACTDZ 15,311,1996
TOXICOLOGY REVIEW
ENTOX* -,104,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2104;
Number of Industries 8;
Total Number of Facilities 164;
Number of Occupations 17;
Total Number of Employees Exposed 3,929
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M2104;
Number of Industries 9;
Total Number of Facilities 516;
Number of Occupations 16;
Total Number of Employees Exposed 20,479;
Total Number of Female Employees Exposed 1,215


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for dyeing textiles, sheepskins and furs, and for coloring polymethyl methacrylate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
AJCDE* American Journal of Contact Dermatitis: Official Journal of the American Contact Dermatitis Society (Philadelphia, PA : W.B. Saunders, Harcourt Brace Jovanovich) V.1-14 1990-2003.
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-

Used for dyeing textiles, sheepskins and furs, and for coloring polymethyl methacrylate

NIOSH PROFILE (AMINOAZOBENZENES), SRC, 11/81

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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