RTECS:AB1000000 The Registry of Toxic Effects of Chemical Substances

Acenaphthene

RTECS #: AB1000000

CAS #: 83-32-9

UPDATE: May 2009 MW: 154.22 MF: C₁₂H₁₀

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

1,2 - Dihydroacenaphthylene

1,8 - Ethylenenaphthalene

Acenaphthylene, 1,2 - dihydro -

Naphthyleneethylene

peri - Ethylenenaphthalene

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
cytogenetic analysis hamster lung 10 mmol/L/6 hour (+enzymatic activation step) MUREAV 517,187,2002
mutation in microorganisms other microorganisms 3 mg (-enzymatic activation step) MIKBA5 54,360,1985
mutation in microorganisms Salmonella typhimurium 0.5 nmol/plate/48 hour (-enzymatic activation step) MUREAV 557,99,2004
mutation in microorganisms Salmonella typhimurium 55,556 pmol/L (+enzymatic activation step) MUREAV 626,88,2007

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
rat lethal dose (50 percent kill): 600 mg/kg N/R VCVGH* -,230,1990
intratracheal
rat lowest published toxic dose: 100 mg/kg Kidney, Ureter, and Bladder: Other changes VCVGH* -,230,1990

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 12 mg/m³/4 hour/22 week- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis) GTPZAB 14(6),46,1970
unreported route
mouse lowest published toxic dose: 180 mg/kg/12 day- intermittent Immunological Including Allergic: Uncharacterized (multiple organ involvement) TOXID9 48,13,1999

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 540,89,2003
TOXICOLOGY REVIEW
MUREAV 558,155,2004
TOXICOLOGY REVIEW
MUREAV 558,7,2004
TOXICOLOGY REVIEW
TOLED5 140-141,353,2003
TOXICOLOGY REVIEW
MUREAV 566,209,2004
TOXICOLOGY REVIEW
ENTOX* -,11,2005
TOXICOLOGY REVIEW
MUREAV 681,93,2009

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m³, JUN2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4337;
Number of Industries 12;
Total Number of Facilities 485;
Number of Occupations 14;
Total Number of Employees Exposed 1,920
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4337;
Number of Industries 3;
Total Number of Facilities 164;
Number of Occupations 3;
Total Number of Employees Exposed 1,064

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS PB/95/264370)
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a dye intermediate, insecticide, fungicide and for manufacture of plastics
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC, 5506; by GC, 5515

REFERENCES:
CODEN
REFERENCE**

ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
MIKBA5 Mikrobiologiya. Microbiology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1932-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a dye intermediate, insecticide, fungicide and for manufacture of plastics

RTECS Compound Description:
Mutagen

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SYNONYMS:
1,2 - Dihydroacenaphthylene 1,8 - Ethylenenaphthalene Acenaphthylene, 1,2 - dihydro -	Naphthyleneethylene peri - Ethylenenaphthalene

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
cytogenetic analysis	hamster lung	10 mmol/L/6 hour (+enzymatic activation step)	MUREAV 517,187,2002
mutation in microorganisms	other microorganisms	3 mg (-enzymatic activation step)	MIKBA5 54,360,1985
mutation in microorganisms	Salmonella typhimurium	0.5 nmol/plate/48 hour (-enzymatic activation step)	MUREAV 557,99,2004
mutation in microorganisms	Salmonella typhimurium	55,556 pmol/L (+enzymatic activation step)	MUREAV 626,88,2007

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal rat	lethal dose (50 percent kill): 600 mg/kg	N/R	VCVGH* -,230,1990
intratracheal rat	lowest published toxic dose: 100 mg/kg	Kidney, Ureter, and Bladder: Other changes	VCVGH* -,230,1990

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation rat	lowest published toxic concentration: 12 mg/m³/4 hour/22 week- intermittent	Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)	GTPZAB 14(6),46,1970
unreported route mouse	lowest published toxic dose: 180 mg/kg/12 day- intermittent	Immunological Including Allergic: Uncharacterized (multiple organ involvement)	TOXID9 48,13,1999

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		MUREAV 540,89,2003
TOXICOLOGY REVIEW		MUREAV 558,155,2004
TOXICOLOGY REVIEW		MUREAV 558,7,2004
TOXICOLOGY REVIEW		TOLED5 140-141,353,2003
TOXICOLOGY REVIEW		MUREAV 566,209,2004
TOXICOLOGY REVIEW		ENTOX* -,11,2005
TOXICOLOGY REVIEW		MUREAV 681,93,2009

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Occupational Exposure Limit - RUSSIA	short term exposure limit 10 mg/m³, JUN2003

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: M4337; Number of Industries 12; Total Number of Facilities 485; Number of Occupations 14; Total Number of Employees Exposed 1,920
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: M4337; Number of Industries 3; Total Number of Facilities 164; Number of Occupations 3; Total Number of Employees Exposed 1,064

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264370)
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a dye intermediate, insecticide, fungicide and for manufacture of plastics
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC, 5506; by GC, 5515

REFERENCES:
CODEN	REFERENCE
ENTOX*	Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GTPZAB	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
MIKBA5	Mikrobiologiya. Microbiology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1932-
MUREAV	Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOLED5	Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9	Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVGH*	"Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.