The Registry of Toxic Effects of Chemical Substances
Abrin RTECS #: AA5250000
CAS #: 1393-62-0
The Registry of Toxic Effects of Chemical Substances
Abrin |
| UPDATE: August 2006 | MW: N/R | MF: N/R |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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DNA inhibition
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mouse
| Ascites tumor
50 µg/kg
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TOXIA6 11,379,1973
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DNA inhibition
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mouse
embryo
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10 µg/L
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APTOA6 57,328,1985
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other mutation test systems
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mouse
embryo
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10 µg/L
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APTOA6 57,328,1985
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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intraperitoneal | mouse
lowest published toxic dose: 6,672 µg/kg (7-14 day pregnant)
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Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Other developmental abnormalities
EJVSAU 24,135,1987
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
inhalation | rat
lethal concentration (50 percent kill): 3.3 µg/kg
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N/R
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JAPTO* 23,139,2003
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intraperitoneal | mouse
lethal dose (50 percent kill): 20 µg/kg
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N/R
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TOXIA6 9,97,1971
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intraperitoneal | mouse
lowest published lethal dose: 0.4 µg/kg
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N/R
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TXCYAC 214,268,2005
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intravenous | mouse
lethal dose (50 percent kill): 0.5 µg/kg
|
N/R
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JAPTO* 23,139,2003
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intravenous | rabbit
lethal dose (50 percent kill): 0.5 µg/kg
|
N/R
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JAPTO* 23,139,2003
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oral | human
lowest published lethal dose: 7 µg/kg
|
N/R
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85KYAH 11,2,1989
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oral | rat
lowest published lethal dose: 300 mg/kg
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Gastrointestinal: Hypermotility, diarrhea | Gastrointestinal: Peritonitis Behavioral: Muscle weakness
AMIHAB 12,468,1955
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oral | rabbit
lowest published lethal dose: 21 mg/kg
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Gastrointestinal: Hypermotility, diarrhea | Gastrointestinal: Peritonitis Behavioral: Muscle weakness
AMIHAB 12,468,1955
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unreported route | mouse
lethal dose (50 percent kill): 20 µg/kg
|
N/R
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TOXIA6 13,127,1975
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
intraperitoneal | mouse
lowest published toxic dose: 75,060 µg/kg/90 day- intermittent
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Blood: Changes in leukocyte (WBC) count | Blood: Changes in platelet count
EJVSAU 24,138,1987
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
TOXICOLOGY REVIEW
|
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BIPAA8 74,85,1976
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TOXICOLOGY REVIEW
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TXCYAC 214,210,2005
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
N/R
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N/R
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N/R
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
N/R
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REFERENCES:
CODEN
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REFERENCE
85KYAH
|
"Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ
07065, Merck & Co., Inc. 1989
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AMIHAB
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AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher
information, see AEHLAU.
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APTOA6
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Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher
information, see PHTOEH
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BIPAA8
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Bulletin de l'Institut Pasteur (Paris). (SPPIF, B.P.22, F-41353 Vineuil, France) V.1-
1903-
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EJVSAU
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Egyptian Journal of Veterinary Science. (National Information and Documentation Centre,
A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt) V.9- 1972-
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JAPTO*
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Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex,
PO22 9SA England) V.1- 1981-
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TOXIA6
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Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962-
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TXCYAC
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Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
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