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NIOSH Skin Notation Profiles

NIOSH Scientific Information Quality - Peer Review Agenda

Document

NIOSH Skin Notation Profiles

Required Elements for Initial Public Posting

Subject: NIOSH Skin Notation Profiles

Purpose: Provide information about the health risks associated with dermal contact and uptake of specific high priority workplace chemicals.

Timing of Review: Public comment period for 14 profiles: May 2015 – June 2015. Public comment period for 10 profiles: November 2013 – January 2014, Peer review during public comment period.

Primary Disciplines or Expertise Needed for Review: Toxicology, risk assessment, industrial hygiene, occupational medicine

Type of Review: Individual

Number of Reviewers: 2-3 reviewers per Skin Notation Profile

Reviewers Selected by: NIOSH

Public Nominations Requested for Reviewers: No

Opportunities for the Public to Comment: Yes

Peer Reviewers Provided with Public Comments Before Their Review: No

Charge to Peer Reviewers

The purpose of the technical review is to review the technical validity of the scientific information in these documents. If there are errors of fact, unsubstantiated claims, evidence of careless experimental work, inclusion of too much information already in the literature, or statements that are inaccurate, please note such in your review comments.

  1. Does this document clearly outline the systemic health hazards associated with exposures of the skin to the chemical? If not, what specific information is missing from the document?
  2. If the SYS or SYS (FATAL) notations are assigned, is the rationale and logic behind the assignment clear? If not assigned, is the logic clear why it was not (e.g., insufficient data, no identified health hazard)?
  3. Does this document clearly outline the direct (localized) health hazards associated with exposures of the skin to the chemical? If not, what specific information is missing from the document?
  4. If the DIR, DIR (IRR), or DIR (COR) notations are assigned, is the rationale and logic behind the assignment clear? If not assigned, is the logic clear why it was not (e.g., insufficient data, no identified health hazard)?
  5. Does this document clearly outline the immune-mediated responses (allergic response) health hazards associated with exposures of the skin to the chemical? If not, what specific information is missing from the document?
  6. If the SEN notation is assigned, is the rationale and logic behind the assignment clear? If not assigned, is the logic clear why it was not (e.g., insufficient data, no identified health hazard)?
  7. If the ID(SK) or SK were assigned, is the rationale and logic outlined within the document?
  8. Are the conclusions supported by the data?
  9. Are the tables clear and appropriate?
  10. Is the document organized appropriately? If not, what improvements are needed?
  11. Are you aware of any scientific data reported in governmental publications, databases, peer reviewed journals, or other sources that should be included within this document?
 
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  • Page last reviewed: October 29, 2013
  • Page last updated: May 8, 2015
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