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Activities: NIOSH Funded Research Grants

NIOSH sponsors research and training through its extramural programs, which complement the Institute's intramural programs. More information is available from the NIOSH Office of Extramural Programs.

Report of Respiratory Disease Research Program Extramural Funding

Intramural research and extramural research both are critical to the success of RDRP at NIOSH. The following information describes extramural research funded by NIOSH during the period 1994-2006.

Web links are provided to abstracts for individual funded research projects as posted on the National Institute of Health’s Computer Retrieval of Information on Scientific Projects (CRISP) web site.

Extramural funding by disease category (see also Figure 1).

Figure 1: Total extramural funding (research dollars) by fiscal year 1996-2006

Total Extramural Funding 1994-2006
Airways Disease$28,891,356
Interstitial Disease$6,752,282
Infectious Disease$3,769,410

Airways Disease

From 1994-2006, fifty extramural projects were identified to be specific to Airways Diseases research. These Airways Diseases research projects received $28,891,356. Figure 2 shows the funding levels by year for extramural Airways Disease research.

Figure 2: Extramural funding for Airways disease research by fiscal year 1996-2006

Airways Disease Extramural ProjectsStartEnd
Expanded occupational health surveillance in ma7/1/066/30/10
Expanded occupational health surveillance in ma7/1/056/30/10
Organic dust epithelial pkc activation & airway disease8/1/067/31/10
Genetics susceptibility for occupational asthma9/1/068/31/10
Towards a better understanding of work-aggravated asthma9/30/058/31/10
Lung disease in Chinese textile workers9/30/957/30/10
Assessing and controlling occupational health risks to immigrants in Somerville8/1/057/31/09
Longitudinal study of respiratory function in aluminum smelter workers9/1/068/31/09
Indoor environment and symptoms in office building9/1/048/31/07
Longitudinal study of isocyanate asthma in body shops9/30/029/30/07
Dermal exposure to 1,6-hexamethylene diisocyanate8/1/037/31/06
Personal displacement ventilation8/15/048/14/06
Occupational asthmagens in cleaners: a focus group study9/1/046/30/06
Nail salon hazards and health effects9/1/038/31/06
Farm related asthma9/30/039/29/06
Physiologic characterization of occupational asthma9/1/028/31/05
Isocyanate exposure intervention study in body shops9/30/029/29/05
An indoor environment design tool for entire buildings8/1/017/31/04
Chronic obstructive pulmonary disease risks in carpenter9/30/029/29/04
Childhood agricultural trauma evaluation system9/30/009/29/04
Initial respiratory responses welding apprentices9/30/009/29/04
Childhood agricultural trauma evaluation system9/30/009/29/04
Floor-supply displacement ventilation system9/30/019/29/04
A validated asthma questionnaire for healthcare workers9/30/019/29/04
Environmental factors in alpha 1-antitrypsin deficiency6/1/015/31/03
Initial respiratory responses welding apprentices9/30/009/29/03
Chemokine biomarkers of diisocyanate occupational asthma9/30/999/29/03
Ventilation control to reduce airborne contaminants4/1/993/31/02
Isocyanate asthma in autobody shops9/1/978/31/02
Health effects of exposures to vocs, ozone and stress9/30/999/29/02
Novel hydrogen sulfide sensors for portable monitors9/30/013/31/02
Irritant-induced asthma: epidemiology and pathogenesis9/30/999/29/02
Occupational asthma associated with seafood processing9/30/999/29/02
Peak exposures in aluminum smelting9/30/999/29/02
Personal aerosol sampler for occupational environments2/1/981/31/01
Biomarkers of smoke exposure among firefighters9/30/989/29/01
Adult asthma as a predictor of work loss and disability9/30/979/29/01
Respiratory health in pot room work--an inception cohort9/30/979/29/01
Time & scuba tank use on injury prevention/fire fighters9/30/989/29/01
Microanalytical system for indoor voc monitoring9/30/989/29/01
Novel mouse model of isocyanate induced asthma9/30/989/30/00
Respiratory disease among sawmill workers9/30/989/30/00
New approaches to cross sectional studies of asthma9/30/979/29/00
Hazmat firefighters--medical and incident surveillance6/1/965/31/99
Charge distributions of indoor aerosol particles9/1/978/31/99
Fuel oil ash, host factors and lung function9/30/969/29/99
Lung disease in Chinese textile workers9/30/959/29/99
Chronic sinusitis and occupational respiratory disease9/30/969/29/98
New sampling and analysis method for isocyanates5/1/954/30/97
Endotoxin epidemiology and exposure assessment9/30/949/29/97
Interstitial Lung Disease

Extramural funding for Interstitial Lung Disease research was $6,752,282 distributed among 21 projects. Figure 3 shows the extramural funding levels of interstitial disease research (1996-2006).

Figure 3: Extramural funding for interstitial lung diseases research by fiscal year 1996-2006

Interstitial Diseases Extramural ProjectsStartEnd
Mycobacteria in metalworking fluids7/1/056/30/08
New Mexico occupational health surveillance7/1/056/30/08
Genetic/exposure interaction in beryllium disease8/1/037/31/06
Pulmonary effects of machining fluid aerosols9/1/939/29/04
Control measures for silica exposures for tuck pointing9/30/029/29/04
Molecular analysis of mycobacteria in cutting fluids9/30/019/30/04
Cytotoxicity and solubility of beryllium particles6/1/015/31/03
Job hazard analysis of sandblasting substitutes8/1/007/31/03
Silica exposure & silicosis: effect of mixed exposures9/30/019/30/03
Evaluation of a surveillance radiograph standards set9/30/009/29/03
Iron, calcium and oxidative stress in lung injury9/30/999/29/02
Evaluation of dust control technologies in construction9/30/999/29/01
Occupational lung disease in a flocking plant5/1/19996/30/00
Pulmonary effects of machining fluid aerosols9/1/939/29/00
Estimation of highest task silica exposures9/30/989/29/00
Computer assisted chest radiograph reader9/30/983/31/99
Asbestos induced chest disease--quantitative ct analysis9/30/959/29/98
Protein damage caused by occupational toxicants6/1/935/31/96
Pulmonary effects of machining fluid aerosols9/1/938/31/96
Asbestos induced alteration in endothelial cell function9/30/049/29/96
Automating staging of coal workers pneumoconiosis6/1/9411/30/95

Extramural funding for research into occupational respiratory malignancies was $12,947,428 to support 28 projects. Figure 4 shows the historical extramural funding support for malignancy support.

Figure 4: Extramural funding for Lung Malignancy disease research by fiscal year 1996-2006

Respiratory Malignancy Extramural ProjectsStartEnd
Control of workplace diesel exhaust particulate8/1/057/31/08
Airborne heavy metal monitor9/30/999/29/01
Mesothelioma virtual bank for translational research9/1/068/31/08
Smoking bans and health: effects of exposure on the job7/1/056/30/07
P53 biomarker and intervention in occupational cancer6/1/025/31/05
P53 biomarker and intervention in occupational cancer7/1/066/30/10
Silica, silicosis, and lung cancer in diatomite workers4/1/943/31/96
Inhalation dosimetry/exposure index of fiber aerosol9/1/028/31/07
Real-time personal monitor for the dry cleaning industry9/1/048/31/06
Florida firefighter cancer incidence and mortality6/1/005/31/02
Airborne heavy metal monitor9/30/975/30/98
Respiratory carcinogenesis in uranium miners9/30/949/29/97
Fe(ii) and dust induced carcinogenesis9/30/949/29/96
Reactive intermediates in gene regulation by asbestos4/1/973/31/00
Metalworking fluids and aerodigestive cancer risk8/1/997/31/01
Chrysotile: new exposure indices and cancer epidemiology9/30/039/29/07
Stochastic models for radiation carcinogenesis: tempora*9/30/029/29/05
Toxicokinetics of ethyl tertiary-butyl ether9/30/979/29/00
Validation of biomarkers in humans exposed to PAHs1/1/0212/31/04
Time-factors in exposure effects among uranium workers5/1/024/30/04
03 and modulating cr toxicity and the lung3/1/992/28/02
Occupational exposure to aflatoxin5/1/916/30/97
In-vitro mordenite fiber dissolution at acidic ph9/30/019/29/03
Combined effect of radiation & asbestos in producing pul7/1/996/30/02
Dermal absorption enhancers affect organotropism9/30/999/29/02
Stress genes as biomarkers of mineral dust exposure9/30/949/29/97
03 and modulating cr toxicity and the lung3/1/992/28/03
Mortality in workers with intermittent asbestos exposure9/30/959/29/97
*Funding ended ($0 captured for FY06)
Infectious Disease

Extramural funding of $3,769,410 supported 13 research projects related to respiratory infectious disease research. Figure 5 shows the RDRP level of extramural funding by year for all infectious disease research.

Figure 5: Extramural funding for Infectious lung disease research by fiscal year 1996-2006

Infectious Disease Extramural ProjectsStartEnd
Experimental and theoretical study of early detection and isolation influenza8/1/067/31/09
Worksite-associated vanadium and immunomodulation5/1/934/30/96
Risk of infectious disease in prison based hcws9/30/989/29/00
Innovative hcw training: infectious disease risk9/30/019/29/03
Respirator efficacy versus tuberculosis aerosols6/1/995/31/01
Evaluation of portable samplers for viable bioaerosols9/1/048/31/07
Design/advanced electrostatic sampler for total bioaerosols8/1/067/31/08
Ultraviolet lights in hvac systems--effect on health and9/30/999/29/01
Prevention of ieq related absence--an intervention study9/30/989/29/01
Testing interventions to human-generated occupational airborne infections8/1/067/31/11
Exposure and risk assessment for infectious aerosols6/1/966/30/99
Characteristics of respirators protecting against tb2/1/951/31/98
Electrostatic sampling of airborne microorganisms9/30/979/29/00

Nanoparticles are still a relatively new area of research that started receiving extramural funding in 2001. To date, $2,720,740 in extramural funds has been allocated to 7 projects involved in nanoparticle research. Figure 6 shows the extramural funding by year to support respiratory disease-related nanotechnology research.

Figure 6: Extramural funding for Nanotechnology research by fiscal year 1996-2006

Nanoparticle Extramural ProjectsStartEnd
Lung oxidative stress/inflammation by carbon nanotubes7/10/056/30/09
Science to achieve results (star) program8/1/067/31/09
Assessment methods for nanoparticles in the workplace7/1/056/30/08
Monitor & characterize airborne carbon nanotube particles8/1/057/31/08
New nanostructured sensor arrays for hydride detection8/1/062/28/07
From nanoparticles to novel protective garments9/1/045/15/05
On-board diagnostic sensor for respirator breakthrough9/30/009/29/04
Cross-Cutting Areas

This category accounts for research projects that do not exclusively fit into only one of the five RDRP categories described as strategic goal areas. We characterized 74 projects as cross-cutting, which received total extramural funding of $32,915,281. The 74 Cross-Cutting projects were further divided into five sub-categories identified as Engineering Controls, Exposure Assessment, Respiratory Protection, Surveillance and Other (Aerosols/Exposure-Sector/Substitution). Projects related to Surveillance, 22% ($7,283,745), Exposure Assessment, 23% ($7,589,854), and Other, 44% ($14,394,955) accounted for the bulk of total Cross-Cutting funding support.

Figure 7: Extramural funding for “Cross-Cutting” research by fiscal year 1996-2006

Engineering Controls Cross-Cutting ProjectsStartEnd
Computational methods in industrial ventilation9/30/959/29/98
Field validation of ventilation troubleshooting method4/1/943/31/97
Enclosing hood effectiveness8/1/067/31/09
Developing exposure control by material balance modeling6/1/985/31/00
Factors that affect generation of coolant mists9/30/959/29/97
Improving the work environment in livestock buildings9/30/999/29/01
Microbiological characterization and mitigation of bioaerosols in cafos9/15/069/14/10
Model development for the design of better mist filters8/1/007/31/02
Transport modeling of industrial ventilation9/30/939/29/96
Evaluation of voc exposures in ventilated rooms9/30/009/29/03


Exposure Assessment Cross-Cutting ProjectsStartEnd
Real-time in situ aerosol monitoring in mine atmospheres9/1/028/31/06
On-site enumeration of fungal spores and bacteria in air2/1/921/31/96
Fundamental study of welding fume inhalation8/1/057/31/08
Multi-hazard sensor for miners9/1/063/31/07
Comparison of concentrations at personal locations7/1/016/30/04
Inhalation and sampling of large particles, 10-150 um9/30/949/29/97
New method for real-time measurement of diesel aerosol8/1/057/31/08
Microrelectrochemical sensors for hazardous material detection8/1/062/28/07
Passive sampler for particles9/30/989/30/00
Development of personal electrostatic sampler9/30/946/30/95
Theory and evaluation of a workplace op-ftir monitor9/1/898/31/96
Absorption of gas phase contaminant mixtures9/30/009/29/03
Exposure assessment tools for multiple pollutants9/1/048/31/06
Carbonyl compounds air sampling method9/1/958/31/98
Methods for assessing synthetic textile dust exposure9/30/999/29/01
Retrospective exposure assessment in industrial settings4/1/973/31/00
Evaporative losses from semi-volatile mist samples5/1/004/30/03
New methods for eval of organic dust aerosols8/1/027/31/07
A new air sampling system for long-term sampling8/1/057/31/07
Biological monitoring of wood smoke exposure9/1/028/31/04
Aerosol sampler performance characteristics9/1/948/31/97
Methods for developing and testing aerosol samplers9/1/945/31/02
Development of new personal aerosol samplers9/30/989/29/01
Workplace aerosol sampling at realistic low wind speeds9/1/048/31/07
Micromachined system for selective measurement of vocs9/15/939/29/97
Novel hydrogen sulfide sensors for portable monitors9/16/039/15/05
Multiple velocity aerosol sampling inlets to conform9/30/973/31/99
Physiologic sampler for airborne health hazards9/30/939/29/96
Small, selective multivapor monitoring instrument9/30/952/28/99


Respiratory Protection Cross-Cutting ProjectsStartEnd
Respirator effects in impaired workers7/15/057/14/10
Absorption of gas phase contaminants8/3/057/31/08
Escape respirators for first responders8/1/062/28/07
Respiratory protection against bioaerosol in agriculture6/1/015/31/04
Statistical modeling of respirator penetration data7/1/996/31/01
On-board diagnostic sensor for respirator breakthrough9/30/006/30/01
System for measuring workplace protection factors9/30/9912/31/99
Lighter compact respirators for toxic vapor protection9/30/923/31/96


Surveillance Cross-Cutting ProjectsStartEnd
Washington occupational surveillance program7/1/056/30/10
Occupational safety and health surveillance in new york7/1/056/30/10
Occupational safety and health surveillance in new york7/1/066/30/10
California occupational safety and health surveillance7/1/056/30/10
Enhanced program in occupational injury and illness sur*7/1/056/30/10
Fundamental & expanded occupational health surveillance7/1/056/30/10
Core surveillance of occupational health in new york7/1/016/30/05
Occupational surveillance modules for prevention7/1/016/30/05
Surveillance methods for health care and related workers9/30/019/29/05
*Funding ended ($0 captured for FY06)


Other (Aerosols/Exposure-Sector/Substitution) Cross-Cutting ProjectsStartEnd
Aerosol ScienceNumerical modeling of aerosol concentration9/30/019/30/04
Aerosol ScienceA study of aerosol transport using vortex methods9/30/999/29/01
Aerosol ScienceFibrous aerosols in narrow size ranges8/1/937/31/98
Aerosol ScienceFeedback control of particles in fluid media4/1/943/31/96
Aerosol ScienceFibrous aerosols in narrow size ranges8/1/937/31/96
EconomicsCosts of occupational injury and illness6/1/055/31/10
Exposure-SectorThe western center for agricultural health and safety at uc davis9/30/069/29/11
Exposure-SectorIntervention effectiveness in finish agriculture8/1/057/31/08
Exposure-SectorCertified safe farm evaluating health insurance claims9/1/038/31/07
Exposure-SectorHazardous substance training for emergency responders9/30/029/29/07
Exposure-SectorConference on occupational & environmental health9/1/052/28/06
Exposure-SectorMicrobiological air contamination from machining fluids9/30/019/29/03
Exposure-SectorAgricultural injuries in Finland8/1/007/31/02
Exposure-SectorMachining fluid microbiology and health9/30/989/29/00
Exposure-SectorWood dust intervention study for small business9/30/959/29/99
Exposure-SectorGrain dust exposure--physiologic and biologic correlates8/1/937/31/96
Exposure-SectorOccupational disease among carpenters9/30/9312/31/95
SubstitutionReduced mist generation with mircopcm machining coolants9/30/983/31/99


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