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Manufacturing

NORA Manufacturing Sector Strategic Goals

927Z1LF - Update: Cadmium/Arsenic Lung Cancer Exposure Response

Start Date: 10/1/2005
End Date: 9/30/2009

Principal Investigator (PI)
Name: Robert Park
Phone: 513-533-8572
E-mail: rhp9@cdc.gov
Organization: NIOSH
Sub-Unit: EID
Funded By: NIOSH

Primary Goal Addressed
6.0

Secondary Goal Addressed
5.0


Attributed to Manufacturing

100%


Project Description

Short Summary

Using an updated cohort with more years of followup and enhanced characterization of both cadmium and arsenic exposures, a new estimate of the cadmium-lung cancer exposure response will be generated along with a risk assessment identifying lifetime excess risk for different levels of cadmium.



Description

A new retrospective assessment of arsenic exposures has been conducted and concentrations have been modeled. An additional 5 years of mortality followup has been performed. Careful review and data cleanup will be completed dealing with problems in the personnel records and some confusion on how overtime was recorded. The analysis will utilize both the traditional NIOSH life-table approach as well as Poisson regression modeling of lung cancer mortality rates. Based on the best model, risk assessment calculations will be performed.





Objectives

Using an updated cohort with more years of followup and enhanced characterization of both cadmium and arsenic exposures, a new estimate of the cadmium-lung cancer exposure response will be generated along with a risk assessment identifying lifetime excess risk for different levels of cadmium.



Mission Relevance

Cadmium is a suspect lung carcinogen which has implications for users of pigments, certain brazing operations, battery manufacture, plating operations, some assembly work, and others. Previous estimates of the cadmium-lung cancer exposure response have been challenged on grounds that co-exposure to arsenic was not sufficiently addressed. This project will update mortality followup for a cadmium cohort, apply a more detailed and comprehensive retrospective exposure assessment, including enhanced characterization of arsenic levels, and generate a new estimate of the cadmium-lung cancer risk. This project contributes to the following sectors:



Manufacturing Sector (100%)

Goal 5. Reduce the number of respiratory conditions and diseases due to exposures in the manufacturing sector.

Goal 6. Reduce the prevalence of cancer due to exposures in the manufacturing sector.



This project also contributes to the Cross-Sector Programs:



Cancer, Reproductive, and Cardiovascular Disease (50%)

Goal 1 Reduce the incidence of work-related cancer.

1.1.a Conduct analytic epidemiology studies of high-priority, high-feasibility populations and exposures.

1.1.e Develop methods for quantitative cancer risk assessments in support of authoritative recommendations for limiting occupational exposures.



Respiratory Diseases (50%)

Goal 4. Prevent and reduce work-related respiratory malignancies.



 
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