NORA Manufacturing Sector Strategic Goals
9277176 - NORA Cancer Research Methods TeamStart Date: 9/30/2008
End Date: 10/1/2012
Principal Investigator (PI)Name: Paul Schulte
Funded By: NIOSH
Primary Goal Addressed6.0
Secondary Goal AddressedNone
Attributed to Manufacturing50%
Over the past decades, there have been major advances in understanding the molecular events leading to cancer. The Cancer Research Methods NORA Team has focused on methods and data needs that might close this gap, ranging from current data on industrial production and uses of chemicals to techniques for screening chemicals for potential carcinogenicity, to the predictive value of intermediate effect markers in occupational cohorts. An important goal is to be able to recognize potential carcinogens before occupational exposure manifests in excess cancer risk.
Over the past decades, there have been major advances in understanding the molecular events leading to cancer, but there is still a gap in utilizing this knowledge to prevent occupational cancer. The Cancer Research Methods Team is focusing on methods and data needs that might close this gap.
The goal of this project is to increase the capacity for occupational cancer research. To achieve this goal, a number of objectives should be met. These include: development of priorities for which cancer research methods should be addressed and selection of the most important priorities for further action. Specific objectives include: (a) addressing data gaps pertaining to IARC Class 2A, 2B, and 3 carcinogens; (b) developing systematic approaches for cross-sectional studies (involving intermediate effect biomarkers) of occupational groups; and (c) developing a fellowship and training program for new occupational cancer investigators.
•Describe the problems or needs and why they are important to address.