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IMMUNE, DERMAL AND INFECTIOUS DISEASES

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Dermal Diseases

Activities: NIOSH Funded Research Grants

NIOSH sponsors research and training through its extramural programs, which complement the Institute's intramural programs. More information is available from the NIOSH Office of Extramural Programs. Our Research Portfolio includes the following NIOSH funded research grants:

Mechanistically-Based In Silico Estimation of Dermal Absorption in the Workplace

The goal of this study is to develop and apply to occupational risk assessment a sophisticated, yet accessible mathematical model that closely mimics percutaneous penetration, tissue concentrations and clearance of chemicals in human skin in vivo.

Division: Office of Extramural Programs
Phone: 404-498-2530
Project period: 09/01/07 - 08/31/12

Quantitating Absorption of Complex Chemical Mixtures

The study proposes that skin is a primary route of exposure for many chemicals and that most chemical exposure occurs in mixtures. This will be investigated by using 1. membrane-coated fibers, sensitive to solvatochromatic processes predicted by QSPR models, 2. silicone membrane flow through diffusion cells, sensitive to solvatochromatic processes 3. porcine skin flow through diffusion cells, sensitive to changes in lipid permeability, and 4. isolated perfused porcine skin flaps, sensitive to irritation and vascular events. The PI proposes to use MCF to predict a compounds' initial diffusion into skin. Develop a more quantitative and reproducible approach for assessing complex chemical mixture exposure, using novel humane alternative animal model systems with direct relevance to predicting dermal absorption in humans.

Division: Office of Extramural Programs
Phone: 404-498-2530
Project period: 06/01/01 - 03/31/10

 

 
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  • Page last reviewed: December 18, 2012
  • Page last updated: December 18, 2012
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