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Modifying welding process parameters can reduce the neurotoxic potential of manganese-containing welding fumes.

Authors
Sriram-K; Lin-GX; Jefferson-AM; Stone-S; Afshari-A; Keane-MJ; McKinney-W; Jackson-M; Chen-BT; Schwegler-Berry-D; Cumpston-A; Cumpston-JL; Roberts-JR; Frazer-DG; Antonini-JM
Source
Toxicology 2015 Feb; 328:168-178
NIOSHTIC No.
20045513
Abstract
Welding fumes (WF) are a complex mixture of toxic metals and gases, inhalation of which can lead to adverse health effects among welders. The presence of manganese (Mn) in welding electrodes is cause for concern about the potential development of Parkinson's disease (PD)-like neurological disorder. Consequently, from an occupational safety perspective, there is a critical need to prevent adverse exposures to WF. As the fume generation rate and physicochemical characteristics of welding aerosols are influenced by welding process parameters like voltage, current or shielding gas, we sought to determine if changing such parameters can alter the fume profile and consequently its neurotoxic potential. Specifically, we evaluated the influence of voltage on fume composition and neurotoxic outcome. Rats were exposed by whole-body inhalation (40mg/m3; 3h/day×5 d/week×2 weeks) to fumes generated by gas-metal arc welding using stainless steel electrodes (GMA-SS) at standard/regular voltage (25V; RVSS) or high voltage (30V; HVSS). Fumes generated under these conditions exhibited similar particulate morphology, appearing as chain-like aggregates; however, HVSS fumes comprised of a larger fraction of ultrafine particulates that are generally considered to be more toxic than their fine counterparts. Paradoxically, exposure to HVSS fumes did not elicit dopaminergic neurotoxicity, as monitored by the expression of dopaminergic and PD-related markers. We show that the lack of neurotoxicity is due to reduced solubility of Mn in HVSS fumes. Our findings show promise for process control procedures in developing prevention strategies for Mn-related neurotoxicity during welding; however, it warrants additional investigations to determine if such modifications can be suitably adapted at the workplace to avert or reduce adverse neurological risks.
Keywords
Manganese-compounds; Welding; Welders; Neurological-diseases; Neurological-reactions; Neurological-system; Aerosols; Aerosol-particles; Fumes; Neurotoxins; Neurotoxicity; Neurotoxic-effects; Neurotoxicology; Gas-welders; Arc-welders; Arc-welding; Particulate-dust; Particulates; Metal-fumes; Metals; Metalworking; Metalworking-industry; Author Keywords: Manganese; Neurotoxicity; Parkinsonism; Parkinsons disease; Prevention; Welding
Contact
Krishnan Sriram, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
CODEN
TXCYAC
CAS No.
7439-96-5
Publication Date
20150203
Document Type
Journal Article
Email Address
kos4@cdc.gov
Fiscal Year
2015
NTIS Accession No.
NTIS Price
ISSN
0300-483X
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Toxicology
State
WV
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