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Thinking small: new approaches for evaluating the toxicologic pathology of nanotechnology products.

Authors
Hubbs-AF; Sargent-LM; Sriram-K; Nurkiewicz-TR; Castranova-V; Porter-D; Reynolds-SH; Lowry-D; Fluharty-KL; Mercer-RR
Source
64th Annual Meeting of the American College of Veterinary Pathologists and 48th Annual Meeting of the American Society for Veterinary Clinical Pathology, Proceeding of the ACVP/ASVCP Concurrent Annual Meetings, November 16-20, 2013, Montréal, Québec, Canada, Madison, WI: American College of Veterinary Pathologists, 2013 Nov; :1-11
NIOSHTIC No.
20045472
Abstract
Nanotechnology involves matter that is in the nanoscale size range. The products of nanotechnology are increasingly impacting fields of electronics, aerospace engineering, cosmetics and medicine. Toxicologic pathologists are familiar with ultrastructural pathology and, therefore, with biological processes of nanoscale dimensions. Not surprisingly, when particulates are similar in size to biological structures, the in vivo toxicity can be very different than for larger particulates with the same chemical composition. In evaluating the toxicologic pathology of these smallest of engineered products, the potential may exist for movement across biological barriers, interaction with subcellular structures, transport within lymphatics and neurons, and changes in the chemical and physical properties of the test agent. This is a brief introduction to considerations for toxicologic pathology studies of nanotechnology products.
Keywords
Nanotechnology; Toxicopathology; Pathology; Particulates; Biological-function; Biological-systems; Engineering; Biological-transport
Publication Date
20131116
Document Type
Conference/Symposia Proceedings
Fiscal Year
2014
NTIS Accession No.
NTIS Price
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
64th Annual Meeting of the American College of Veterinary Pathologists and 48th Annual Meeting of the American Society for Veterinary Clinical Pathology, Proceeding of the ACVP/ASVCP Concurrent Annual Meetings, November 16-20, 2013, Montréal, Québec, Canada
State
WV
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