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Brainstem auditory evoked potentials in children with lead exposure.

Authors
Alvarenga-KF; Morata-TC; Lopes-AC; Feniman-MR; Corteletti-LC
Source
Braz J Otorhinolaryngol 2015 Jan-Feb; 81(1):37-43
NIOSHTIC No.
20045354
Abstract
Introduction: Earlier studies have demonstrated an auditory effect of lead exposure in children, but information on the effects of low chronic exposures needs to be further elucidated. Objective: To investigate the effect of low chronic exposures of the auditory system in children with a history of low blood lead levels, using an auditory electrophysiological test. Methods: Contemporary cross-sectional cohort. Study participants underwent tympanometry, pure tone and speech audiometry, transient evoked otoacoustic emissions, and brainstem auditory evoked potentials, with blood lead monitoring over a period of 35.5 months. The study included 130 children, with ages ranging from 18 months to 14 years, 5 months (mean age 6 years, 8 months +/- 3 years, 2 months). Results: The mean time-integrated cumulative blood lead index was 12 microg/dL (SD +/- 5.7, range: 2.433). All participants had hearing thresholds equal to or below 20 dBHL and normal amplitudes of transient evoked otoacoustic emissions. No association was found between the absolute latencies of waves I, III, and V, the interpeak latencies I---III, III---V, and I---V, and the cumulative lead values. Conclusion: No evidence of toxic effects from chronic low lead exposures was observed on the auditory function of children living in a lead contaminated area.
Keywords
Auditory-system; Biological-effects; Lead-compounds; Children; Chronic-exposure; Exposure-assessment; Blood-sampling; Audiological-testing; Electrophysiological-examinations; Audiometry; Biological-monitoring; Hearing-threshold; Hearing; Acoustics; Author Keywords: Toxicity; Lead poisoning; Brainstem auditory evoked potentials; Pure-tone audiometry
Contact
Lilian Cassia Bornia Jacob Cortelettia, Department of Speech Therapy and Audiology, Faculdade de Odontologia de Bauru, Universidade de São Paulo (FOB-USP), Bauru, SP, Brazil
CAS No.
7439-92-1
Publication Date
20150101
Document Type
Journal Article
Email Address
lilianjacob@fob.usp.br
Fiscal Year
2015
NTIS Accession No.
NTIS Price
Identifying No.
M112014
Issue of Publication
1
ISSN
1808-8694
NIOSH Division
DART
Priority Area
Manufacturing; Services
Source Name
Brazilian Journal of Otorhinolaryngology
State
OH
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