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Health assessment of gasoline and fuel oxygenate vapors: neurotoxicity evaluation.

Authors
O'Callaghan-JP; Daughtrey-WC; Clark-CR; Schreiner-CA; White-R
Source
Regul Toxicol Pharmacol 2014 Nov; 70(2)(Suppl):S35-S42
NIOSHTIC No.
20045341
Abstract
Sprague-Dawley rats were exposed via inhalation to vapor condensates of either gasoline or gasoline combined with various fuel oxygenates to assess potential neurotoxicity of evaporative emissions. Test articles included vapor condensates prepared from "baseline gasoline" (BGVC), or gasoline combined with methyl tertiary butyl ether (G/MTBE), ethyl t-butyl ether (G/ETBE), t-amyl methyl ether (G/TAME), diisopropyl ether (G/DIPE), ethanol (G/EtOH), or t-butyl alcohol (G/TBA). Target concentrations were 0, 2000, 10,000 or 20,000 mg/mg3 and exposures were for 6 h/day, 5 days/week for 13 weeks. The functional observation battery (FOB) with the addition of motor activity (MA) testing, hematoxylin and eosin staining of brain tissue sections, and brain regional analysis of glial fibrillary acidic protein (GFAP) were used to assess behavioral changes, traditional neuropathology and astrogliosis, respectively. FOB and MA data for all agents, except G/TBA, were negative. G/TBA behavioral effects resolved during recovery. Neuropathology was negative for all groups. Analyses of GFAP revealed increases in multiplebrain regions largely limited to males of the G/EtOH group, findings indicative of minor gliosis, most significantly in the cerebellum. Small changes (both increases and decreases) in GFAP were observed for other test agents but effects were not consistent across sex, brain region or exposure concentration.
Keywords
Animals; Laboratory-animals; Vapors; Neurotoxicity; Emission-sources; Exposure-levels; Methyl-compounds; Brain-function; Brain-damage; Proteins; Behavior; Neuropathology; Fuels; Author Keywords: Neurotoxicity; Glial fibrillary acidic protein (GFAP); Astrogliosis; Gasoline vapor condensates; Methyl tertiary butyl ether; mEthyl t-butyl ether; t-Amyl methyl ether; Diisopropyl ether; Ethanol; t-Butyl alcohol
Contact
Charles R. Clark, 5901 Woodland Road, Bartlesville, OK 74006
CODEN
RTOPDW
CAS No.
108-20-3; 64-17-5; 1634-04-4; 637-92-3; 994-05-8; 75-65-0
Publication Date
20141101
Document Type
Journal Article
Email Address
castox@comcast.net
Fiscal Year
2015
NTIS Accession No.
NTIS Price
Identifying No.
M112014
Issue of Publication
2
ISSN
0273-2300
NIOSH Division
HELD
Priority Area
Construction; Manufacturing
Source Name
Regulatory Toxicology and Pharmacology : RTP
State
WV; NJ; OK; PA; DC
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