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Insomnia in shift work disorder (SWD) associated with cortical excitability: an ERP study prior to a night shift.

Authors
Gumenyuk-V; Howard-R; Roth-T; Roehrs-T; Drake-C
Source
Sleep 2013 Jun; 36(Abstract Suppl):A199
NIOSHTIC No.
20045335
Abstract
Introduction: Hyperarousal as a characteristic of primary insomnia may be reflected in neuronal excitability of the central auditory system. Currently, it is unknown whether insomnia (INS) in the context of shift work (SWD-INS) is characterized by elevated amplitude of the N1 auditory brain response measured by event-related brain potentials (ERPs). Insomnia is also associated with cognitive processing deficits. This study examined the N1 as a measure of neuronal excitability and the MMN as a measure of cognitive processing in SWD-INS during the night. Methods: 5 night-workers with SWD-INS (38+/-10.3yrs. 1 male; ESS 7.8+/-1.2: ISI 15.5+/-3.9) and 9 asymptomatic night workers (ANW) (31.5+/-5.5yrs, 3 males; ESS 7.9+/-1.7: lSI 6.6+/-2.8) participated. All worked a 10-12hr shift between 19:00 and 08:00 and were free of other sleep disorders and otherwise healthy. The ERP session started at 18:00. The peak latency of N1 elicited by an infrequent sound (frequency deviant) was measured between 90-110 ms from sound onset. The MMN was elicited when the brain pre-attentively detected a frequency change in the sound-sequence and was measured between 130-160 ms from sound onset. Evaluation of sleepiness was performed by a standard MLST starting at 22:30. Results: Mean MSLT score from 22:30 - 02:30 was not significantly different between groups (9+/-5min [ANW] vs. 10+/-8min [SWD-INS]), but the ISI differed (15.5+/-3.9 [SWD-INS] vs. 6.6+/-2.8 [ANW] p<.02). The N1 amplitude was significantly elevated in SWD-INS relative to ANW (-1.7+/-O.8 microV vs. -1.1+/-0.6 microV, p<0.0 1). MMN was not significantly different between SWD-INS and ANW (-0.9 microV+/-0.8 microV vs. -1.0 microV+/-0.7microV). Conclusion: Cortical excitability is present in SWD-INS and can be objectively determined by the N1 brain response in the auditory modality. In the wake state, SWD-INS is not associated with a deficit of sensory memory.
Keywords
Sleep-deprivation; Sleep-disorders; Shift-work; Shift-workers; Brain-electrical-activity; Brain-function; Brain-matter; Auditory-system; Work-intervals; Humans; Men; Age-groups; Physiological-response; Sound; Sensory-perceptual-processes; Mental-processes; Nervous-system
Contact
V. Gumenyuk, Sleep Disorders and Research Center, Henry Ford Hospital, Detroit, MI, USA
CODEN
SLEED6
Publication Date
20130601
Document Type
Abstract
Funding Type
Grant
Fiscal Year
2013
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-009996
ISSN
0161-8105
Source Name
Sleep
State
MI
Performing Organization
Henry Ford Health System, Detroit, Michigan
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