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Evaluation of the pulmonary toxicity of a fume generated from a Nickel-, copper-based electrode to be used as a substitute in stainless steel welding.

Authors
Antonini-JM; Badding-MA; Meighan-TG; Keane-M; Leonard-SS; Roberts-JR
Source
Environ Health Insights 2014 Oct; 8(Suppl 1):11-20
NIOSHTIC No.
20045198
Abstract
Epidemiology has indicated a possible increase in lung cancer among stainless steel welders. Chromium (Cr) is a primary component of stainless steel welding fume. There is an initiative to develop alternative welding consumables [nickel (Ni)- and copper (Cu)-based alloys] that do not contain Cr. No study has been performed to evaluate the toxicity of fumes generated from Ni- and Cu-based consumables. Dose-response and time-course effects on lung toxicity of a Ni- and Cu-based welding fume (Ni-Cu WF) were examined using an in vivo and in vitro bioassay, and compared with two other well-characterized welding fumes. Even though only trace amounts of Cr were present, a persistent increase in lung injury and inflammation was observed for the Ni-Cu WF compared to the other fumes. The difference in response appears to be due to a direct cytotoxic effect by the Ni-Cu WF sample on lung macrophages as opposed to an elevated production of reactive oxygen species (ROS).
Keywords
Epidemiology; Lung; Lung-disorders; Lung-disease; Cancer; Stainless-steel; Steel-compounds; Steelworkers; Welding; Fumes; Bioassays; In-vitro-study; In-vivo-study; In-vitro-studies; In-vivo-studies; Cytotoxic-effects; Author Keywords: welding fume; pulmonary toxicity; chromium; nickel; copper; particulate matter
CODEN
EHINA4
CAS No.
7440-47-3; 7440-02-0; 7440-50-8
Publication Date
20141001
Document Type
Journal Article
Email Address
jga6@cdc.gov
Fiscal Year
2015
NTIS Accession No.
NTIS Price
Identifying No.
M102014
ISSN
1178-6302
NIOSH Division
HELD
Priority Area
Construction
Source Name
Environmental Health Insights
State
WV
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