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Nanoparticles, lung injury, and the role of oxidant stress.

Authors
Madl-AK; Plummer-LE; Carosino-C; Pinkerton-KE
Source
Annu Rev Physiol 2014 Feb; 76:447-465
NIOSHTIC No.
20045197
Abstract
The emergence of engineered nanoscale materials has provided significant advancements in electronic, biomedical, and material science applications. Both engineered nanoparticles and nanoparticles derived from combustion or incidental processes exhibit a range of physical and chemical properties that induce inflammation and oxidative stress in biological systems. Oxidative stress reflects the imbalance between the generation of reactive oxygen species and the biochemical mechanisms to detoxify and repair the damage resulting from reactive intermediates. This review examines current research on incidental and engineered nanoparticles in terms of their health effects on lungs and the mechanisms by which oxidative stress via physicochemical characteristics influences toxicity or biocompatibility. Although oxidative stress has generally been thought of as an adverse biological outcome, this review also briefly discusses some of the potential emerging technologies to use nanoparticle-induced oxidative stress to treat disease in a site-specific fashion.
Keywords
Nanotechnology; Oxidation; Oxidative-processes; Physiological-stress; Immune-reaction; Chemical-properties; Physical-properties; Biochemical-indicators; Biological-effects; Lung-cells; Lung-disorders; DNA-damage; Drugs; Therapeutic-agents; Airborne-particles; Author Keywords: oxidative stress; nanoparticles; carbon nanotubes; ambient particulate matter; lung
Contact
Amy K. Madl, Center for Health and the Environment, University of California, Davis, California, CA 95616, USA
CODEN
ARPHAD
Publication Date
20140201
Document Type
Journal Article
Email Address
akmadl@ucdavis.edu
Funding Type
Cooperative Agreement
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U50-OH-007550; M102014
ISSN
0066-4278
Source Name
Annual Review of Physiology
State
CA
Performing Organization
University of California - Davis
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