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Lung cancer mortality in a combined cohort of North Carolina and South Carolina asbestos textile workers.

Authors
Elliott-L; Loomis-D; Dement-J; Hein-M; Richardson-D; Kuempel-E; Stayner-L
Source
Occup Environ Med 2011Sep; 68(Suppl 1):A22
NIOSHTIC No.
20045171
Abstract
Objectives: Prior studies of asbestos textile workers in two US cohorts (North Carolina (NC) and South Carolina (SC)) found increased risk of lung cancer mortality with exposure to chrysotile asbestos. The risk, however, appeared to increase more steeply in SC, possibly due to differences in statistical methods and/or cohort defi nitions. The objective of this study was to investigate the exposure-disease relationship in a combined cohort, using equivalent inclusion criteria and analysis. Methods: Workers were included after 30 days of employment in a production job during qualifying years, and vital status ascertained through 2003 (2001 for SC). Standardised mortality ratios (SMR) were estimated using national and state-specifi c rates. Associations of lung cancer mortality with cumulative fi bre exposures (measured by phase contrast microscopy, lagged 10 years) were estimated by Poisson regression with adjustment for age, sex, race, birth cohort, decade of follow-up, and plant. Results: The cohort included 6136 workers, contributing 218 631 person-years of observation and 3356 deaths. Mortality from all causes and all cancers, especially lung cancer (SMR 1.93, 95% CI 1.73 to 2.15) was signifi cantly higher than expected. The relative rate for lung cancer was 1.11 (95% CI 1.06 to 1.16) at 100 fi bre-years/ml compared with 0 fi breyears/ ml. Stratifi cation showed different effects in SC (RR 1.65, 95% CI 1.42 to 1.92) than in NC (RR 1.12, 95% CI 1.06 to 1.19).
Keywords
Asbestos-products; Humans; Men; Women; Carcinogens; Exposure-levels; Risk-factors; Lung-cancer; Lung; Pulmonary-disorders; Pulmonary-system; Pulmonary-system-disorders; Respiratory-system-disorders; Textile-workers; Mortality-rates; Morbidity-rates; Fibrous-dusts; Fibrous-bodies
CODEN
OEMEEM
CAS No.
12001-29-5; 1332-21-4
Publication Date
20110907
Document Type
Abstract
Funding Type
Grant
Fiscal Year
2011
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007803
ISSN
1351-0711
NIOSH Division
EID
Source Name
Occupational and Environmental Medicine
State
NV; NE; NC; OH; IL
Performing Organization
University of Nevada, Reno
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