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Manganese accumulation in bone following chronic exposure in rats: steady-state concentration and half-life in bone.

Authors
O'Neal-SL; Hong-L; Fu-S; Jiang-W; Jones-A; Nie-LH; Zheng-W
Source
Toxicol Lett 2014 Aug; 229(1):93-100
NIOSHTIC No.
20045034
Abstract
Literature data indicate that bone is a major storage organ for manganese (Mn), accounting for 43% of total body Mn. However, the kinetic nature of Mn in bone, especially the half-life (t(1/2)), remained unknown. This study was designed to understand the time-dependence of Mn distribution in rat bone after chronic oral exposure. Adult male rats received 50 mg Mn/kg (as MnCl2) by oral gavage, 5 days per week, for up to 10 weeks. Animals were sacrificed every 2 weeks during Mn administration for the uptake study, and on day 1, week 2, 4, 8, or 12 after the cessation at 6-week Mn exposure for the t(1/2) study. Mn concentrations in bone (MnBn) were determined by AAS analysis. By the end of 6-week's treatment, MnBn appeared to reach the steady state (T(ss)) level, about 2-3.2 fold higher than MnBn at day 0. Kinetic calculation revealed t(1/2)s of Mn in femur, tibia, and humerus bone of 77 (r=0.978), 263 (r=0.988), and 429 (r=0.994) days, respectively; the average t(1/2) in rat skeleton was about 143 days, equivalent to 8.5 years in human bone. Moreover, MnBn were correlated with Mn levels in striatum, hippocampus, and CSF. These data support MnBn to be a useful biomarker of Mn exposure.
Keywords
Bone-structure; Manganese-compounds; Animals; Laboratory-animals; Exposure-levels; Risk-factors; Environmental-exposure; Neurotoxicity; Biomarkers; Health-hazards; Hazards; Statistical-analysis; Author Keywords: Manganese; Biomarker; Bone; Half-life; Disposition
Contact
Wei Zheng, School of Health Science, Purdue University, 550 Stadium Mall Drive, CIVL 1173
CODEN
TOLED5
CAS No.
7439-96-5
Publication Date
20140817
Document Type
Journal Article
Email Address
wzheng@purdue.edu
Funding Type
Grant
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-010044; M092014
Issue of Publication
1
ISSN
0378-4274
Source Name
Toxicology Letters
State
IN
Performing Organization
Purdue University, West Lafayette, Indiana
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