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In vivo processing of ceria nanoparticles inside liver: impact on free-radical scavenging activity and oxidative stress.

Authors
Graham-UM; Tseng-MT; Jasinski-JB; Yokel-RA; Unrine-JM; Davis-BH; Dozier-AK; Hardas-SS; Sultana-R; Grulke-EA; Butterfield-DA
Source
ChemPlusChem 2014 Aug; 79(8):1083-1088
NIOSHTIC No.
20045022
Abstract
The cytotoxicity of ceria ultimately lies in its electronic structure, which is defined by the crystal structure, composition, and size. Despite previous studies focused on ceria uptake, distribution, biopersistance, and cellular effects, little is known about its chemical and structural stability and solubility once sequestered inside the liver. Mechanisms will be presented that elucidate the in vivo transformation in the liver. In vivo processed ceria reveals a particle-size effect towards the formation of ultrafines, which represent a second generation of ceria. A measurable change in the valence reduction of the second-generation ceria can be linked to an increased free-radical scavenging potential. The in vivo processing of the ceria nanoparticles in the liver occurs in temporal relation to the brain cellular and protein clearance responses that stem from the ceria uptake. This information is critical to establish a possible link between cellular processes and the observed in vivo transformation of ceria. The temporal linkage between the reversal of the pro-oxidant effect (brain) and ceria transformation (liver) suggests a cause-effect relationship.
Keywords
Nanotechnology; Particulates; In-vivo-study; Cellular-function; Cellular-reactions; Cytotoxicity; Oxidative-processes; Liver; Free-radicals; Liver-cells; Brain-function; Biotransformation; Crystal-structure; Cerium-compounds; Oxidation-reduction-reactions; Chemical-reactions; Chemical-structure; Author Keywords: biotransformations; cellular chemistry; cerium; nanoparticles; redox chemistry
Contact
Dr. U. M. Graham, Center for Applied Energy Research and Catalysis Research and Testing Center, University of Kentucky, 2540 Research Park Drive, Lexington, KY 40511 USA
CODEN
CHEMM5
CAS No.
1306-38-3
Publication Date
20140801
Document Type
Journal Article
Email Address
graham@liquasol.com
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
M092014
Issue of Publication
8
ISSN
2192-6506
NIOSH Division
DART
Priority Area
Manufacturing
Source Name
ChemPlusChem
State
KY; OH
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