A conference entitled Tenth Anniversary of the U.S. Needlestick Safety and Prevention Act: Mapping Progress, Charting a Future Path was held November 5-6, 2010, in Charlottesville, Virginia. It was organized by the International Healthcare Worker Safety Center (IHWSC) at the University of Virginia (UVa) School of Medicine. In addition to celebrating the tenth anniversary of a historic piece of occupational safety and health legislation (H.R. 5178, the Needlestick Safety and Prevention Act [NSPA]), the purpose of the conference was to assess progress achieved in the decade since the law was passed and identify areas where further progress was needed. The conference was attended by approximately 100 people representing a variety of sectors and stakeholders, including clinicians, researchers, healthcare administrators, representatives from government agencies, professional associations, and the medical device industry. The conference also had global participation, with speakers from Asia, Europe, Africa, and North and South America. A number of medical device companies exhibited at the conference. Key outcomes of the conference: (1) The efficacy of the NSPA in reducing needlestick injury rates and risk of occupational blood exposures was supported by data presented at the conference. This is a major public health achievement that has had and will continue to have an impact on countries around the world, as they seek to emulate the U.S. success in this area. Such evidence also provides support for government policies and regulations intended to support injury prevention and worker protection, both in the U.S. and worldwide. (2) Non-hospital (outpatient care) and surgical settings were identified as two healthcare settings in need of greater attention and focus in the years ahead by all relevant stakeholders. (3) Consensus Statement: to provide guidance for future efforts in the field of sharps safety, conference participants called for the development of a consensus statement; the result document, "Moving the Sharps Safety Agenda Forward: Consensus Statement and Call to Action," was endorsed by the American Nurses Association and 18 other healthcare organizations, and was published in a special supplement of the ANA's journal, American Nurse Today (Sept. 2012). The Consensus Statement can be viewed on-line at: http://www.healthsystem.virginia.edu/pub/epinet/ConsensusStatementOnSharpsInjuryPrevention.pdf.