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Development of a transportable neutron activation analysis system to quantify manganese in bone in vivo: feasibility and methodology.

Authors
Liu-Y; Koltick-D; Byrne-P; Wang-H; Zheng-W; Nie-HL
Source
Physiol Meas 2013 Dec; 34(12):1593-1609
NIOSHTIC No.
20044909
Abstract
This study was conducted to investigate the methodology and feasibility of developing a transportable neutron activation analysis (NAA) system to quantify manganese (Mn) in bone using a portable deuterium-deuterium (DD) neutron generator as the neutron source. Since a DD neutron generator was not available in our laboratory, a deuterium-tritium (DT) neutron generator was used to obtain experimental data and validate the results from Monte Carlo (MC) simulations. After validation, MC simulations using a DD generator as the neutron source were then conducted. Different types of moderators and reflectors were simulated, and the optimal thicknesses for the moderator and reflector were determined. To estimate the detection limit (DL) of the system, and to observe the interference of the magnesium (Mg) y line at 844 keV to the Mn y line at 847 keV, three hand phantoms with Mn concentrations of 30 parts per million (ppm), 150 ppm, and 500 ppm were made and irradiated by the DT generator system. The Mn signals in these phantoms were then measured using a 50% high-efficiency high-purity germanium (HPGe) detector. The DL was calculated to be about 4.4 ppm for the chosen irradiation, decay, and measurement time. This was calculated to be equivalent to a DL of about 3.3 ppm for the DD generator system. To achieve this DL with one 50% high-efficiency HPGe detector, the dose to the hand was simulated to be about 37 mSv, with the total body equivalent dose being about 23ÁSv. In conclusion, it is feasible to develop a transportable NAA system to quantify Mn in bone in vivo with an acceptable radiation exposure to the subject.
Keywords
Manganese-compounds; Bone-marrow; Metabolism; Analytical-processes; Humans; Men; Women; Uranium-compounds; Magnesium-compounds
Contact
Linda H Nie, School of Health Sciences, Purdue University, West Lafayette, IN 47907
CODEN
PMEAE3
CAS No.
7439-95-4; 7439-96-5; 7440-61-1
Publication Date
20131201
Document Type
Journal Article
Email Address
hnie@purdue.edu
Funding Type
Grant
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-010044; Grant-Number-T42-OH-008432
Issue of Publication
12
ISSN
0967-3334
Source Name
Physiological Measurement
State
IN
Performing Organization
Purdue University, West Lafayette, Indiana
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