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Fiber deposition in the tracheobronchial region: comparison of experimental data and theoretical models.

Authors
Zhou-Y; Su-W-C; Ahmadi-G; Hopke-PK; Chen-Y-S
Source
Proceedings of the Seventh International Aerosol Conference, September 10-15, 2006, St. Paul, Minnesota, USA.. Biswas P, Chen DR, Hering S, eds. Mount Laurel, NJ: American Association for Aerosol Research, 2006 Sep; :905
Link
NIOSHTIC No.
20044870
Abstract
Health diseases as a result of fiber inhalation are related to the deposition of those fibers in the lung. Once the fibers have deposited, their acute or chronic effects depend upon a number of additional factors, but unless they can reach a target zone of the respiratory tract, they cannot produce the aforementioned effects. Mechanisms of fiber deposition in various regions of the human respiratory tract have been proposed and mathematical equations developed. However, few experimental data confirm the model prediction. There is still no human data available from controlled experiments of inhaled fiber aerosols for the obvious reason that most fiber materials are potentially hazardous when inhaled. The other reason is that it is very difficult to produce test fiber particles of uniform diameter and length required for this kind of study. In this study, fibers were delivered into two human lung replica to investigate the fiber deposition behaviors in human lungs. The experimental data were also compared with the prediction of several theoretical models.
Keywords
Exposure-levels; Inhalation-studies; Particulates; Fibrous-bodies; Models; Respiration; Pulmonary-function; Pulmonary-system; Diseases; Lung; Lung-disorders; Fibrous-glass; Aerosols; Aerosol-particles; Mathematical-models; Hazards
Publication Date
20060901
Document Type
Abstract
Editors
Biswas-P; Chen-DR; Hering-S
Funding Type
Grant
Fiscal Year
2006
NTIS Accession No.
NTIS Price
ISBN No.
9780978873509
Identifying No.
Grant-Number-R01-OH-003900
Source Name
Proceedings of the Seventh International Aerosol Conference, September 10-15, 2006, St. Paul, Minnesota, USA.
State
NM; NY
Performing Organization
Lovelace Biomedical & Environmental Research, Albuquerque, New Mexico
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