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Computer simulation of ellipsoidal particle transport and deposition in human tracheobronchial tree with 3-D symmetric and asymmetric bifurcation model.

Authors
Tian-L; Ahmadi-G; Hopke-PK; Chen-Y-S
Source
Proceedings of the Seventh International Aerosol Conference, September 10-15, 2006, St. Paul, Minnesota, USA.. Biswas P, Chen DR, Hering S, eds. Mount Laurel, NJ: American Association for Aerosol Research, 2006 Sep; :908-909
Link
NIOSHTIC No.
20044869
Abstract
The study of particle transport in human airways has attracted much attention due to its significance in better understanding of personal exposure and for developing effective devices for inhalation drug delivery. While most of previous study was focused on spherical particles, many environmental particulate pollutants are non-spherical and are elongated particles and fibers. For example asbestos is know to be serious health hazard. In this study, computer simulations are conducted to investigate the transport and deposition of elongated ellipsoidal particles of various size, aspect ratio, and particle-to-fluid densities in human tracheobronchial bifurcation model under mild to moderate breathing conditions. Current study is focused on Generation 0 and 1 of the tracheobronchial tree as suggested by Weibel (1963) classification. The three dimensional airflow fields were first simulated. The ellipsoidal particle transport equation incorporated translational and rotational motion under the coupled effects of hydrodynamic drag force, shear induced lift force, gravitational force, and hydrodynamic torque. The simulation results provide an understanding of the motion of ellipsoidal particles in human tracheobronchial tree. The simulation result are compared with experimental data and discussed.
Keywords
Humans; Exposure-levels; Inhalation-studies; Particulates; Fibrous-bodies; Asbestos-fibers; Models; Respiration; Pulmonary-function; Pulmonary-system; Author Keywords: Ellipsoidal Particle; Fiber Deposition; Particle Deposition; Human Tracheobronchial Tree; Laminar; Turbulence
Publication Date
20060901
Document Type
Abstract
Editors
Biswas-P; Chen-DR; Hering-S
Funding Type
Grant
Fiscal Year
2006
NTIS Accession No.
NTIS Price
ISBN No.
9780978873509
Identifying No.
Grant-Number-R03-OH-008130
Source Name
Proceedings of the Seventh International Aerosol Conference, September 10-15, 2006, St. Paul, Minnesota, USA.
State
NY; NM
Performing Organization
Clarkson University
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