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The effects of carbon nanotubes on lung and dermal cellular behaviors.

Authors
Luanpitpong-S; Wang-L; Rojanasakul-Y
Source
Nanomed 2014 May; 9(6):895-912
NIOSHTIC No.
20044828
Abstract
Carbon nanotubes (CNTs) hold great promise to create new and better products, but their adverse health effect is a major concern. Human exposure to CNTs is primarily through inhalation and dermal contact, especially during the manufacturing and handling processes. Numerous animal studies have demonstrated the potential pulmonary and dermal hazards associated with CNT exposure, while in vitro studies have assessed the effects of CNT exposure on various cellular behaviors and have been used to perform mechanistic studies. In this review, we provide an overview of the pathological effects of CNTs and examine the acute and chronic effects of CNT exposure on lung and dermal cellular behaviors, beyond the generally discussed cytotoxicity. We then examine the linkage of cellular behaviors and disease pathogenesis, and discuss the pertinent mechanisms.
Keywords
Nanotechnology; Inhalants; Skin-exposure; Hazards; In-vitro-study; In-vitro-studies; Cell-function; Cellular-function; Cellular-reactions; Lung; Lung-cells; Lung-function; Cytotoxicity; Pathogens; Pathogenesis; Author Keywords: angiogenesis; carbon nanotubes; carcinogenicity; cellular behavior; cytotoxicity; dermal exposure; genotoxicity; inflammation; lung fibrosis; pulmonary exposure
Contact
Yon Rojanasakul, West Virginia University, Mary Babb Randolph Cancer Center, Morgantown, WV 26506
CODEN
NLUKAC
Publication Date
20140501
Document Type
Journal Article
Email Address
yrojan@hsc.wvu.edu
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
M082014
Issue of Publication
6
ISSN
1743-5889
NIOSH Division
HELD
Priority Area
Manufacturing
Source Name
Nanomedicine
State
WV
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