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Recovery of vascular function after exposure to a single bout of segmental vibration.

Authors
Krajnak-K; Waugh-S; Miller-GR; Johnson-C
Source
J Toxicol Environ Health, A 2014 Sep; 77(17):1061-1069
NIOSHTIC No.
20044775
Abstract
Work rotation schedules may be used to reduce the negative effects of vibration on vascular function. This study determined how long it takes vascular function to recover after a single exposure to vibration in rats (125 Hz, acceleration 5g). The responsiveness of rat-tail arteries to the vasoconstricting factor UK14304, an 2C-adrenoreceptor agonist, and the vasodilating factor acetylcholine (ACh) were measured ex vivo 1, 2, 7, or 9 d after exposure to a single bout of vibration. Vasoconstriction induced by UK14304 returned to control levels after 1 d of recovery. However, re-dilation induced by ACh did not return to baseline until after 9 d of recovery. Exposure to vibration exerted prolonged effects on peripheral vascular function, and altered vascular responses to a subsequent exposure. To optimize the positive results of work rotation schedules, it is suggested that studies assessing recovery of vascular function after exposure to a single bout of vibration be performed in humans.
Keywords
Vibration; Hand-tools; Repetitive-work; Risk-factors; Biological-effects; Biological-factors; Biological-monitoring; Biomechanical-modeling; Biomechanics; Exposure-assessment; Exposure-levels; Injury-prevention; Laboratory-animals; Laboratory-techniques; Mathematical-models; Measurement-equipment; Physiological-effects; Physiological-response; Quantitative-analysis; Statistical-analysis; Tools; Vasomotor-system; Vasomotor-system-disorders; Vibration-effects; Vibration-exposure
Contact
Kristine Krajnak, Ph.D, NIOSH, 1095 Willowdale Rd, MS2027, Morgantown, WV 26505
CODEN
JTEHD6
Publication Date
20140901
Document Type
Journal Article
Email Address
ksk1@cdc.gov
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
M072014
Issue of Publication
17
ISSN
1528-7394
NIOSH Division
HELD
Source Name
Journal of Toxicology and Environmental Health, Part A: Current Issues
State
WV
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