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Longitudinal design for sonographic measurement of median nerve swelling with controlled exposure to physical work using an animal model.

Authors
Roll-SC; Evans-KD; Volz-KR; Sommerich-CM
Source
Ultrasound Med Biol 2013 Dec; 39(12):2492-2497
NIOSHTIC No.
20044750
Abstract
In the study described here, we examined the feasibility of a longitudinal design to measure sonographically swelling of the median nerve caused by controlled exposure to a work task and to evaluate the relationship of changes in morphology to diagnostic standards. Fifteen macaques, Macaca fascicularis, pinched a lever in various wrist positions at a self-regulated pace (8 h/d, 5 d/wk, 18-20 wk). Nerve conduction velocity (NCV) and cross-sectional area (CSA) were measured every 2 wk from baseline through working and a 6-wk recovery. Trending across all subjects revealed that NCV slowed and CSA at the carpal tunnel increased in the working arm, whereas no changes were observed in CSA either at the forearm or for any measure in the non-working arm. There was a small negative correlation between NCV and CSA in the working arm. This study provides validation that swelling can be observed using a longitudinal design. Longitudinal human studies are needed to describe the trajectory of nerve swelling for early identification of median nerve pathology.
Keywords
Animals; Laboratory-animals; Carpal-tunnel-syndrome; Diseases; Models; Nerve-function; Ultrasound; Author Keywords: Median mononeuropathy; Sonography; Carpal tunnel syndrome
Contact
Shawn C. Roll, Division of Occupational Science and Occupational Therapy, University of Southern California, 1540 Alcazar Street, CHP 133, Los Angeles, CA 90089-9003
CODEN
USMBA3
Publication Date
20131201
Document Type
Journal Article
Email Address
sroll@usc.edu
Funding Type
Grant
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-009131; Grant-Number-R21-OH-009907
Issue of Publication
12
ISSN
0301-5629
Source Name
Ultrasound in Medicine & Biology
State
OH
Performing Organization
Ohio State University
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