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Lung function more than a decade after World Trade Center (WTC) exposure: the influences of bronchial reactivity and corticosteroid therapy.

Authors
Aldrich-TK; Dhar-S; King-C; Crosse-T; Weakley-J; Christodoulou-V; Banauch-GI; Berger-KI; Weiden-MD; Hall-CB; Ye-F; Webber-MP; Prezant-DJ
Source
Am J Respir Crit Care Med 2014 May; 189(Meeting Abstracts):A6495
NIOSHTIC No.
20044740
Abstract
Rationale: Inhalation of dust and toxins during rescue/recovery work at the WTC site led to an average 439ml decline in FEV1 for FDNY firefighters in the first post-9/11 year. Approximately 15% demonstrated new obstructive airways disease (OAD) and approximately 25% demonstrated bronchial hyperreactivity (BHR). This study assesses the subsequent (2002-2013) course of BHR and lung function among those with and without OAD, BHR, and corticosteroid treatment. Methods: From January to October 2013, 154 firefighters (72% never-smokers) with normal pre-9/11 spirometry, who had received methacholine challenge tests (MCT) within 2 years of 9/11/2001, underwent full lung function testing, including repeat MCT performed off respiratory medications. To adjust for aging, FEV1 was expressed as percent predicted (FEV1%). The difference between the 2013 FEV1% and the 1st post-9/11 FEV1% was used to describe lung function change subsequent to the initial post-9/11 decline. Results: Initially, post-9/11, 23 firefighters (15%) had BHR (PC20<8mg/ml); 6 of them (26%) were negative (PC20>16mg/ml) in 2013. Of 118 firefighters with initially negative MCTs, 17 (14%) were positive in 2013. 117 firefighters (76%) reported using inhaled and/or oral corticosteroids between 2001-2013. The initial pre-9/11 to post-9/11 FEV1% decline averaged 9.8 percentage points. Thereafter, FEV1% tended to decline further, averaging a 2.7 percentage point decrease over the subsequent 11 years. Excluding 2 firefighters with restrictive disease, a multiple regression model with dependent variable "subsequent" (2002-2013) change in FEV1%, showed significant negative contributions from initial change in FEV1% and smoking (p..005), and a positive contribution from approximate steroid dose (p=.03). Contribution of a composite index of BHR to the model approached statistical significance, with more reactive subjects tending to show decreasing FEV1% (p=.08). As shown in the figure, in firefighters without OAD (top two lines), the presence of BHR predicted greater decline in lung function between 2002-2013; in those with OAD (bottom two lines), the presence of BHR predicted absence of response to treatment (p<.04 for influence of OAD and of BHR on the 2002-2013 change in FEV1%, by 2-way ANOVA). Conclusion: Among WTC-exposed firefighters, new-onset OAD is often, but not always, accompanied by BHR, which may persist for a decade or longer. BHR is significantly associated with worsening lung function between 2002-2013, and helps to explain the persistence of OAD among many firefighters. Post-exposure corticosteroid treatment ameliorated some of the excess lung function decline. These findings suggest a substantial role of airway inflammatory disease in WTC-associated OAD.
Keywords
Fire-fighters; Emergency-responders; Respiratory-system-disorders; Pulmonary-system-disorders; Lung-disorders; Pulmonary-function; Lung-function; Employee-exposure; Employee-health; Pulmonary-function-tests; Spirometry; Long-term-study; Vital-capacity; Particulate-dust; Dust-inhalation; Toxins; Airway-obstruction; Corticosteroids; Drug-therapy
Contact
S. Dhar, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY
CODEN
AJCMED
Publication Date
20140501
Document Type
Abstract
Email Address
sdhar@montefiore.org
Funding Type
Cooperative Agreement
Fiscal Year
2014
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U10-OH-010411; M072014
ISSN
1073-449X
Source Name
American Journal of Respiratory and Critical Care Medicine
State
NY; MA
Performing Organization
Albert Einstein College of Medicine, New York
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